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- W2252876656 abstract "Background: Pancreatic cancer is among the most dismal of human malignancies and prognosis and therapy have not been changed within the last 30 years. The 5-year-survival-rate is lower than 5 % due to late clinical symptoms and poor response to radio- or chemotherapy. The identification of precursor lesions would be much better than diagnosing the carcinoma. These precursor lesions are called »pancreatic intraepithelial neoplasia« (PanIN) and are graduated in grade 1–3, whereas grade 3 is classified as »carcinoma in situ«. Currently no reliable, non-invasive imaging technique (e. g. ultrasound, computed tomography, magnet resonance imaging) exists to verify these PanINs. Methods: Recently a transgenic mouse model of pancreatic cancer was established in which the tumor progression of human pancreatic carcinoma is reproduced. These so called »Pdx-1-Cre; LSL-KrasG12D/+; LSL-Trp53R172H/+ mice« develop PanINs, which transform to invasive growing pancreatic carcinoma. The pancreata of mices in different ages were immunohistochemically stained using α-GLUT- 2-antibodies. Results: An expression of GLUT-2 in murine PanINs was found in PanINs of grade 1B and higher. This finding is associated with an elevated glucose metabolism. Additionally GLUT-2- expression could be demonstrated in human PanINs (n = 60). An immunohistochemical staining of GLUT-2 was detectable in 45/60 human PanINs (75 %), whereas PanINs of grade 1B and higher showed a very extensive expression. Conclusions: For the first time we could demonstrate an elevated glucose metabolism already in murine and human precursor lesions of pancreatic carcinoma. These findings could improve the detection of precursor lesions by PET-CT, in which the tumor detection is based on elevated glucose metabolism." @default.
- W2252876656 created "2016-06-24" @default.
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- W2252876656 date "2010-01-01" @default.
- W2252876656 modified "2023-09-27" @default.
- W2252876656 title "Immunohistochemischer Nachweis der GLUT-2-Expression in PanINs des murinen und humanen Pankreaskarzinoms" @default.
- W2252876656 cites W1964064067 @default.
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- W2252876656 doi "https://doi.org/10.1007/978-3-642-12192-0_24" @default.
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