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• W2252913118 abstract "Background: Phytosomes are recently introduced drug delivery systemand novel botanical formulation to produce lipophilic molecular complex toimprove absorption and bioavailability of phytoconstituent. Quercetin is awell-known flavonoid with different biological effects and contributed in foodpreserving by free radical scavenging activity. However, bioavailability ofQuercetin is an important limiting factor for its antioxidant activities. Purpose:To overcome this limitation, in the present study we aimed to produceQuercetin-loaded nano phytosomes to improve its physicochemical stability andbioavailability. Methods: Quercetin-loaded nano phytosome wasprepared by using phosphatidylcholine (PC) and cholesterol (CH). Quercetin nanophytosomes system was characterized by particle size analyzer and differentialscanning calorimetry (DSC). Results: Results showed that formulationwith the Quercetin: PC: CH molar ratio of 1: 2: 0.2 had lower particle size (80nm) and higher encapsulation efficiency percent (98%). Results also indicatedthat incorporation of cholesterol improved the physical stability of nanophytosome for over three weeks. The DSC data showed that incorporation ofQuercetin in the phospholipid bilayer reduced the phase transition temperatureof bilayer in the nano phytosome structure resulting higher release andbioavailability. Conclusion: Nano phytosomal formulation ofQuercetin showed promising potential in fortification of food products withwater insoluble antioxidants." @default.
• W2252913118 created "2016-06-24" @default.
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• W2252913118 date "2014-09-16" @default.
• W2252913118 modified "2023-09-24" @default.
• W2252913118 title "Nano Phytosomes of Quercetin: A Promising Formulation for Fortification of Food Products with Antioxidants" @default.
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