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• W2252940027 endingPage "782" @default.
• W2252940027 startingPage "773" @default.
• W2252940027 abstract "The effects of micromolar concentrations of Mn2+ on the rat liver mitochondrial Ca2+ cycle were investigated. It was found that the addition of Mn2+ to mitochondria which were cycling 45Ca2+ led to a rapid dose dependent decrease in the concentration of extramitochondrial 45Ca2+ of about 1 nmol/mg of protein. The effect was complete within 30 s, was half maximal with 10 microM Mn2+ and was observed in the presence of 3 mM Mg2+ and 1 mM ATP. It occurred over a broad range of incubation temperatures, pH and mitochondrial Ca2+ loads. It was not observed when either Mg2+ or phosphate was absent from the incubation medium, or in the presence of Ruthenium Red. These findings indicate that micromolar concentrations of Mn2+ stimulate the uptake of Ca2+ by rat liver mitochondria, and provide evidence for an interaction between Mg2+ and Mn2+ in the control of mitochondrial Ca2+ cycling." @default.
• W2252940027 created "2016-06-24" @default.
• W2252940027 creator A5017501975 @default.
• W2252940027 creator A5063926336 @default.
• W2252940027 date "1983-06-15" @default.
• W2252940027 modified "2023-09-25" @default.
• W2252940027 title "Effect of micromolar concentrations of manganese ions on calcium-ion cycling in rat liver mitochondria" @default.
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• W2252940027 doi "https://doi.org/10.1042/bj2120773" @default.
• W2252940027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1153154" @default.
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• W2252940027 hasPublicationYear "1983" @default.
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