Matches in SemOpenAlex for { <https://semopenalex.org/work/W2253058304> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2253058304 abstract "The advancements in systems and synthetic biology have been broadening the range of realizable systems with increasing complexity both in vitro and in vivo. Systems for digital logic operations, signal processing, analog computation, program flow control, as well as those composed of different functions – for example an on-site diagnostic system based on multiple biomarker measurements and signal processing – have been realized successfully. However, the efforts to date tend to tackle each design problem separately, relying on ad hoc strategies rather than providing more general solutions based on a unified and extensible architecture, resulting in long development cycle and rigid systems that require redesign even for small specification changes.Inspired by well-tested techniques adopted in electronics design automation (EDA), this work aims to remedy current design methodology by establishing a standardized, complete flow for realizing biomolecular systems. Given a behavior specification, the flow streamlines all the steps from modeling, synthesis, simulation, to final technology mapping onto implementing chassis. The resulted biomolecular systems of our design flow are all built on top of an FPGA-like reconfigurable architecture with recurring modules. Each module is designed the function of eachmodule depends on the concentrations of assigned auxiliary species acting as the “tuning knobs.” Reconfigurability not only simplifies redesign for altered specification or post-simulation correction, but also makes post-manufacture fine-tuning – even after system deployment – possible. This flexibility is especially important in synthetic biology due to the unavoidable variations in both the deployed biological environment and the biomolecular reactions forming the designed system.In fact, by combining the system’s reconfigurability and neural network’s self-adaptiveness through learning, we further demonstrate the high compatibility of neuromorphic computation to our proposed architecture. Simulation results verified that with each module implementing a neuron of selected model (ex. spike-based, threshold-gate-like, etc.), accompanied by an appropriate choice of reconfigurable properties (ex. threshold value, synaptic weight, etc.), the system built from our proposed flow can indeed perform desired neuromorphic functions." @default.
- W2253058304 created "2016-06-24" @default.
- W2253058304 creator A5032496292 @default.
- W2253058304 date "2015-06-01" @default.
- W2253058304 modified "2023-09-25" @default.
- W2253058304 title "Biomolecular System Design: Architecture, Synthesis, and Simulation" @default.
- W2253058304 cites W1980301976 @default.
- W2253058304 cites W2168898273 @default.
- W2253058304 hasPublicationYear "2015" @default.
- W2253058304 type Work @default.
- W2253058304 sameAs 2253058304 @default.
- W2253058304 citedByCount "0" @default.
- W2253058304 crossrefType "dissertation" @default.
- W2253058304 hasAuthorship W2253058304A5032496292 @default.
- W2253058304 hasConcept C105795698 @default.
- W2253058304 hasConcept C115901376 @default.
- W2253058304 hasConcept C115903868 @default.
- W2253058304 hasConcept C118524514 @default.
- W2253058304 hasConcept C120314980 @default.
- W2253058304 hasConcept C127413603 @default.
- W2253058304 hasConcept C133731056 @default.
- W2253058304 hasConcept C149635348 @default.
- W2253058304 hasConcept C191908910 @default.
- W2253058304 hasConcept C2780149590 @default.
- W2253058304 hasConcept C2780598303 @default.
- W2253058304 hasConcept C31352089 @default.
- W2253058304 hasConcept C33923547 @default.
- W2253058304 hasConcept C37135326 @default.
- W2253058304 hasConcept C41008148 @default.
- W2253058304 hasConcept C60644358 @default.
- W2253058304 hasConcept C76155785 @default.
- W2253058304 hasConcept C78519656 @default.
- W2253058304 hasConcept C86803240 @default.
- W2253058304 hasConceptScore W2253058304C105795698 @default.
- W2253058304 hasConceptScore W2253058304C115901376 @default.
- W2253058304 hasConceptScore W2253058304C115903868 @default.
- W2253058304 hasConceptScore W2253058304C118524514 @default.
- W2253058304 hasConceptScore W2253058304C120314980 @default.
- W2253058304 hasConceptScore W2253058304C127413603 @default.
- W2253058304 hasConceptScore W2253058304C133731056 @default.
- W2253058304 hasConceptScore W2253058304C149635348 @default.
- W2253058304 hasConceptScore W2253058304C191908910 @default.
- W2253058304 hasConceptScore W2253058304C2780149590 @default.
- W2253058304 hasConceptScore W2253058304C2780598303 @default.
- W2253058304 hasConceptScore W2253058304C31352089 @default.
- W2253058304 hasConceptScore W2253058304C33923547 @default.
- W2253058304 hasConceptScore W2253058304C37135326 @default.
- W2253058304 hasConceptScore W2253058304C41008148 @default.
- W2253058304 hasConceptScore W2253058304C60644358 @default.
- W2253058304 hasConceptScore W2253058304C76155785 @default.
- W2253058304 hasConceptScore W2253058304C78519656 @default.
- W2253058304 hasConceptScore W2253058304C86803240 @default.
- W2253058304 hasLocation W22530583041 @default.
- W2253058304 hasOpenAccess W2253058304 @default.
- W2253058304 hasPrimaryLocation W22530583041 @default.
- W2253058304 hasRelatedWork W113123423 @default.
- W2253058304 hasRelatedWork W117245785 @default.
- W2253058304 hasRelatedWork W1894833073 @default.
- W2253058304 hasRelatedWork W2146426878 @default.
- W2253058304 hasRelatedWork W2249662077 @default.
- W2253058304 hasRelatedWork W2288863156 @default.
- W2253058304 hasRelatedWork W2292501494 @default.
- W2253058304 hasRelatedWork W2312584066 @default.
- W2253058304 hasRelatedWork W2396363337 @default.
- W2253058304 hasRelatedWork W2568305616 @default.
- W2253058304 hasRelatedWork W2773522027 @default.
- W2253058304 hasRelatedWork W2907337442 @default.
- W2253058304 hasRelatedWork W2966547560 @default.
- W2253058304 hasRelatedWork W3127745999 @default.
- W2253058304 hasRelatedWork W3159940020 @default.
- W2253058304 hasRelatedWork W3177593432 @default.
- W2253058304 hasRelatedWork W3212316188 @default.
- W2253058304 hasRelatedWork W322339980 @default.
- W2253058304 hasRelatedWork W565094964 @default.
- W2253058304 hasRelatedWork W2181663446 @default.
- W2253058304 isParatext "false" @default.
- W2253058304 isRetracted "false" @default.
- W2253058304 magId "2253058304" @default.
- W2253058304 workType "dissertation" @default.