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- W2253105147 abstract "Extraganglionic actions of ganglionic blocking agents were studied in cats by the simultaneous recording of action potentials of the carotid nerve (afferent) and of the preganglionic portion of the greater splanchnic nerve (efferent). Moderately hypotensive doses of hexamethonium, tetraethylammonium, SU-1194 or SU-2704 administered intravenously decreased blood pressure and splanchnic outflow concomitantly. Continuous low-grade activity replaced the synchronized, high-voltage discharge seen prior to drug administration. Larger doses of the blocking agents (2.0 mgm./kgm. or more of hexamethonium) largely or completely abolished splanchnic activity. Carotid nerve activity was not changed significantly. In contrast, hypotension induced by peripheral vasodilators (acetylcholine or histamine) or by Dibenzyline was associated with a marked increase in splanchnic nerve activity. Activity in the splanchnic nerves induced reflexly by excitation of carotid chemoreceptors by either cholinergic or hypoxic (NaCN) stimuli was considerably reduced by the ganglionic blocking agents. The moderate increase in splanchnic activity which often persisted was of the desynchronized type and no high-voltage bursts, which characteristically followed chemoreceptor activation prior to administration of a ganglionic blocking agent, occurred. This mild increase in splanchnic activity did not cause a rise in blood pressure, probably because of an element of true ganglionic blockade peripheral to the point of recording. Ganglionic transmission of maximal stimuli applied to preganglionic cervical sympathetic neurons was unaltered or only minimally decreased by hypotensive doses of the ganglionic blocking agents. However, responses to near-threshold or prolonged stimulation were more effectively inhibited. These observations suggest that the major effect of moderate doses of these agents on ganglia is to impair temporal summation, and that the continuous, low-voltage activity of preganglionic neurons which follows the administration of the blocking agents would be inhibited more readily at peripheral ganglia than would the normal synchronized high-voltage activity. The relative importance of central and ganglionic blockade in determining responses to ganglionic blocking agents in the intact animal cannot be stated definitely, but it appears probable that theformer is of major importance in the response to large doses, and that both actions are involved, the former facilitating the latter, in the response to moderate doses." @default.
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- W2253105147 date "1957-06-01" @default.
- W2253105147 modified "2023-09-23" @default.
- W2253105147 title "Central and peripheral components of the action of ganglionic blocking agents." @default.
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