FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2253106577> ?p ?o ?g. }

• W2253106577 abstract "Pulte et al. [1] described significant insurance-related disparities among younger patients with non-Hodgkin lymphoma (NHL), with hazard ratios for overall survival of 1.92 and 2.51 in the uninsured or Medicaid populations, respectively. Their findings complement recently identified disparities in diffuse large B-cell lymphoma (DLBCL) survival by socioeconomic status, particularly pronounced among patients less than 65 years old [2]. However, the Surveillance, Epidemiology and End Results data set used by Pulte et al. lacks important confounders of survival in NHL: performance/comorbidity status, human immunodeficiency virus (HIV) status, the International Prognostic Index (IPI) [3], and chemotherapy use. We further explored those insurance-related disparities using the National Cancer Data Base (NCDB), a joint project of the American Cancer Society and the Commission on Cancer of the American College of Surgeons, which captures more than 70% of incident cancer cases in the United States. Advantageously, the NCDB contains data on the Charlson-Deyo comorbidity index [4], HIV status, chemotherapy administration and the IPI in a subset (11%) of all reported DLBCL cases. Among 5,797 patients aged 18–64 years diagnosed with DLBCL between 2004 and 2011, those confounders had a significantly different prevalence among groups with various types of health insurance (Table 1). In particular, nearly a quarter of those younger Medicaid patients were HIV-positive, and more than 40% had high-intermediate or high IPI, compared with only 27% of patients with private insurance. Additionally, Medicaid and Medicare beneficiaries had higher rates of comorbidities. This is explained by eligibility criteria for those state-sponsored programs, which are tied to medical disability in the younger age groups.Table 1.Confounders of survival in diffuse large B-cell lymphoma among patients aged 18–64 years with different types of health coverageIn multivariable Cox models adjusting for age, sex, race, comorbidity index, and stratified by the IPI, HIV status, and stage (which violated the proportional hazard assumption), the adjusted hazard ratios for overall survival were: 1.26 for the uninsured (95% confidence interval [CI], 1.05–1.52), 1.52 for Medicaid (95% CI, 1.31–1.76), and 1.47 for Medicare (95% CI, 1.26–1.71). These estimates, although still significant, were notably lower than those calculated by Pulte et al., indicating that the insurance-associated disparities are partly mediated by prevalence of known prognostic factors in DLBCL or by patients’ pre-existing medical conditions that determine eligibility for specific health insurance. The relative risk of nonreceipt of chemotherapy (adjusted for the same confounders) in a robust Poisson model was 1.58 (95 CI, 1.15–2.18) for the uninsured, 1.60 (95% CI, 1.23–2.09) for Medicaid, and 1.65 (95% CI, 1.24–2.19) for Medicare, demonstrating direct disparity in the delivery of standard curative treatment.Cancer registries constitute a popular data source for the study of disparities, but they offer limited insight into their cause. Our results highlight that to quantify and interpret such disparities, confounders related to patients’ baseline status or disease biology have to be separated from socioeconomic factors affecting health care quality that could respond to policy or system interventions [5, 6]. Another layer of complexity may arise from differences in histologic or molecular characteristics. Those remain largely unexplored, although they may also confound racial or socioeconomic disparities, as recently shown in some hematologic malignancies [7, 8]." @default.
• W2253106577 created "2016-06-24" @default.
• W2253106577 creator A5035051206 @default.
• W2253106577 creator A5058210944 @default.
• W2253106577 date "2015-10-01" @default.
• W2253106577 modified "2023-09-24" @default.
• W2253106577 title "Health Insurance‐Related Disparities in Lymphoma Survival Are Partly Mediated by Baseline Clinical Factors" @default.
• W2253106577 cites W1849371322 @default.
• W2253106577 cites W1972089769 @default.
• W2253106577 cites W2023227841 @default.
• W2253106577 cites W2083358890 @default.
• W2253106577 cites W2123547378 @default.
• W2253106577 cites W2129168200 @default.
• W2253106577 cites W2157438105 @default.
• W2253106577 cites W4205736005 @default.
• W2253106577 doi "https://doi.org/10.1634/theoncologist.2015-0228" @default.
• W2253106577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4591952" @default.
• W2253106577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26432820" @default.
• W2253106577 hasPublicationYear "2015" @default.
• W2253106577 type Work @default.
• W2253106577 sameAs 2253106577 @default.
• W2253106577 citedByCount "3" @default.
• W2253106577 countsByYear W22531065772015 @default.
• W2253106577 countsByYear W22531065772016 @default.
• W2253106577 countsByYear W22531065772017 @default.
• W2253106577 crossrefType "journal-article" @default.
• W2253106577 hasAuthorship W2253106577A5035051206 @default.
• W2253106577 hasAuthorship W2253106577A5058210944 @default.
• W2253106577 hasBestOaLocation W22531065771 @default.
• W2253106577 hasConcept C107130276 @default.
• W2253106577 hasConcept C121608353 @default.
• W2253106577 hasConcept C126322002 @default.
• W2253106577 hasConcept C160735492 @default.
• W2253106577 hasConcept C162324750 @default.
• W2253106577 hasConcept C207103383 @default.
• W2253106577 hasConcept C2776534028 @default.
• W2253106577 hasConcept C2778559949 @default.
• W2253106577 hasConcept C2779159551 @default.
• W2253106577 hasConcept C2779338263 @default.
• W2253106577 hasConcept C44249647 @default.
• W2253106577 hasConcept C50522688 @default.
• W2253106577 hasConcept C71924100 @default.
• W2253106577 hasConcept C74909509 @default.
• W2253106577 hasConceptScore W2253106577C107130276 @default.
• W2253106577 hasConceptScore W2253106577C121608353 @default.
• W2253106577 hasConceptScore W2253106577C126322002 @default.
• W2253106577 hasConceptScore W2253106577C160735492 @default.
• W2253106577 hasConceptScore W2253106577C162324750 @default.
• W2253106577 hasConceptScore W2253106577C207103383 @default.
• W2253106577 hasConceptScore W2253106577C2776534028 @default.
• W2253106577 hasConceptScore W2253106577C2778559949 @default.
• W2253106577 hasConceptScore W2253106577C2779159551 @default.
• W2253106577 hasConceptScore W2253106577C2779338263 @default.
• W2253106577 hasConceptScore W2253106577C44249647 @default.
• W2253106577 hasConceptScore W2253106577C50522688 @default.
• W2253106577 hasConceptScore W2253106577C71924100 @default.
• W2253106577 hasConceptScore W2253106577C74909509 @default.
• W2253106577 hasLocation W22531065771 @default.
• W2253106577 hasLocation W22531065772 @default.
• W2253106577 hasLocation W22531065773 @default.
• W2253106577 hasOpenAccess W2253106577 @default.
• W2253106577 hasPrimaryLocation W22531065771 @default.
• W2253106577 hasRelatedWork W1988845620 @default.
• W2253106577 hasRelatedWork W2047021716 @default.
• W2253106577 hasRelatedWork W2048350640 @default.
• W2253106577 hasRelatedWork W2060262489 @default.
• W2253106577 hasRelatedWork W2105347708 @default.
• W2253106577 hasRelatedWork W2293074300 @default.
• W2253106577 hasRelatedWork W2474165062 @default.
• W2253106577 hasRelatedWork W2597572747 @default.
• W2253106577 hasRelatedWork W2694763134 @default.
• W2253106577 hasRelatedWork W2728695920 @default.
• W2253106577 hasRelatedWork W2766298740 @default.
• W2253106577 hasRelatedWork W2913954358 @default.
• W2253106577 hasRelatedWork W2922334050 @default.
• W2253106577 hasRelatedWork W2969914196 @default.
• W2253106577 hasRelatedWork W2994453233 @default.
• W2253106577 hasRelatedWork W3022084511 @default.
• W2253106577 hasRelatedWork W3106550568 @default.
• W2253106577 hasRelatedWork W3126003151 @default.
• W2253106577 hasRelatedWork W3131490660 @default.
• W2253106577 hasRelatedWork W3174568654 @default.
• W2253106577 isParatext "false" @default.
• W2253106577 isRetracted "false" @default.
• W2253106577 magId "2253106577" @default.
• W2253106577 workType "article" @default.