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• W2253229743 abstract "Abstract Background Patients' quality of life (QoL) deteriorates remarkably after gastrectomy. Billroth I reconstruction following distal gastrectomy has the physiological advantage of allowing food to pass through the duodenum. It was hypothesized that Billroth I reconstruction would be superior to Roux-en-Y reconstruction in terms of long-term QoL after distal gastrectomy. This study compared two reconstructions in a multicentre prospective randomized clinical trial to identify the optimal reconstruction procedure. Methods Between January 2009 and September 2010, patients who underwent gastrectomy for gastric cancer were randomized during surgery to Billroth I or Roux-en-Y reconstruction. The primary endpoint was assessment of QoL using the Functional Assessment of Cancer Therapy – Gastric (FACT-Ga) questionnaire 36 months after surgery. Results A total of 122 patients were enrolled in the study, 60 to Billroth I and 62 to Roux-en-Y reconstruction. There were no differences between the two groups in terms of postoperative complications or mortality, and no significant differences in FACT-Ga total score (P = 0·496). Symptom scales such as epigastric fullness (heaviness), diarrhoea and fatigue were significantly better in the Billroth I group at 36 months after gastrectomy (heaviness, P = 0·040; diarrhoea, P = 0·046; fatigue, P = 0·029). The rate of weight loss in the third year was lower for patients in the Billroth I group (P = 0·046). Conclusion The choice of anastomotic reconstruction after distal gastrectomy resulted in no difference in long-term QoL in patients with gastric cancer. Registration number: NCT01065688 (http://www.clinicaltrials.gov)." @default.
• W2253229743 created "2016-06-24" @default.
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• W2253229743 date "2016-02-03" @default.
• W2253229743 modified "2023-10-16" @default.
• W2253229743 title "Randomized clinical trial comparing long-term quality of life for Billroth I<i>versus</i>Roux-en-Y reconstruction after distal gastrectomy for gastric cancer" @default.
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• W2253229743 doi "https://doi.org/10.1002/bjs.10060" @default.
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