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- W2253352111 abstract "An intramolecular ketene aza-Claisen rearrangement is developed for the first time to enable the stereoselective synthesis of α-ally-α-cyano-lactams from N-allyl amino esters. This reaction also exhibits outstanding chemoselectivity when an unsymmetrical bis-N-allyl group is present in the starting molecule. The usefulness of this method is demonstrated by a short synthesis of optically active bicyclolactam from l-proline." @default.
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- W2253352111 date "2016-02-12" @default.
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- W2253352111 title "One-Pot Conversion of <i>N</i>-Allyl-α-cyano Esters to α-Allyl-α-cyano Lactams through a Hydrolysis/Ketene Formation/Cyclization/Claisen Rearrangement Sequence" @default.
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- W2253352111 doi "https://doi.org/10.1021/acs.orglett.5b02843" @default.
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