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• W2253383790 abstract "The role of immunotherapy in treatment of non-small-cell lung cancer (NSCLC) has been gaining interest over the past few years. This has been driven primarily by promising results from trials evaluating antagonist antibodies that target co-inhibitory immune checkpoints expressed on tumor cells and immune cells within the tumor microenvironment. Immune checkpoints exist to dampen or terminate immune activity to guard against autoimmunity and allow for self-tolerance. However, tumors can take advantage of these immune checkpoint pathways to evade destruction. Antibodies that block inhibitory checkpoints, such as anti-CTLA-4, anti-PD1 and anti-PD-L1 antibodies have demonstrated delayed tumor growth and increased survival. Novel therapies are now investigating combining checkpoint inhibitors with chemotherapy, targeted therapy, radiation and vaccines to produce synergistic antitumor activity." @default.
• W2253383790 created "2016-06-24" @default.
• W2253383790 creator A5008593691 @default.
• W2253383790 creator A5085266293 @default.
• W2253383790 date "2016-03-01" @default.
• W2253383790 modified "2023-10-14" @default.
• W2253383790 title "Immune checkpoint therapy for non-small-cell lung cancer: an update" @default.
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• W2253383790 doi "https://doi.org/10.2217/imt.15.123" @default.
• W2253383790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26860624" @default.
• W2253383790 hasPublicationYear "2016" @default.
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