Matches in SemOpenAlex for { <https://semopenalex.org/work/W2253420912> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2253420912 abstract "The Saccharomyces cerevisiae MGA2 gene encodes a protein that is an important regulator of lipid metabolism in the cell. Mga2p plays a major role in unsaturated fatty acid production through its regulation of the transcription and mRNA stability of OLE1, whose product is the Δ-9 fatty acid desaturase. We have found that mga2Δ strains also contain elevated relative amounts of squalene, a sterol pathway intermediate, when compared to wild-type cells. A possible explanation for the higher squalene levels detected in mga2Δ cells is lower expression of the ERG1 gene. ERG1 encodes squalene epoxidase, which catalyzes the conversion of squalene to squalene epoxide. To explore whether MGA2 plays a role in regulating ERG1 expression, we first examined effects on ERG1 transcription using a promoter-lacZ reporter gene. We report here that in addition to MGA2's role in regulation of unsaturated fatty acids, MGA2 is required for full basal expression of ERG1. In contrast to OLE1, we found that ERG1 expression was not repressed by unsaturated fatty acids. However, ERG1 expression was elevated in response to miconazole, an inhibitor of sterol synthesis in yeast" @default.
- W2253420912 created "2016-06-24" @default.
- W2253420912 creator A5024641108 @default.
- W2253420912 creator A5026558764 @default.
- W2253420912 creator A5029586192 @default.
- W2253420912 creator A5037477340 @default.
- W2253420912 creator A5046067585 @default.
- W2253420912 creator A5054413216 @default.
- W2253420912 creator A5068176375 @default.
- W2253420912 date "2008-03-01" @default.
- W2253420912 modified "2023-09-24" @default.
- W2253420912 title "Role of MGA2 in regulation of lipid metabolism in Saccharomyces cerevisiae" @default.
- W2253420912 doi "https://doi.org/10.1096/fasebj.22.1_supplement.803.3" @default.
- W2253420912 hasPublicationYear "2008" @default.
- W2253420912 type Work @default.
- W2253420912 sameAs 2253420912 @default.
- W2253420912 citedByCount "0" @default.
- W2253420912 crossrefType "journal-article" @default.
- W2253420912 hasAuthorship W2253420912A5024641108 @default.
- W2253420912 hasAuthorship W2253420912A5026558764 @default.
- W2253420912 hasAuthorship W2253420912A5029586192 @default.
- W2253420912 hasAuthorship W2253420912A5037477340 @default.
- W2253420912 hasAuthorship W2253420912A5046067585 @default.
- W2253420912 hasAuthorship W2253420912A5054413216 @default.
- W2253420912 hasAuthorship W2253420912A5068176375 @default.
- W2253420912 hasConcept C104317684 @default.
- W2253420912 hasConcept C143065580 @default.
- W2253420912 hasConcept C150194340 @default.
- W2253420912 hasConcept C165864922 @default.
- W2253420912 hasConcept C185592680 @default.
- W2253420912 hasConcept C19038510 @default.
- W2253420912 hasConcept C2776703722 @default.
- W2253420912 hasConcept C2777129432 @default.
- W2253420912 hasConcept C2777576037 @default.
- W2253420912 hasConcept C2777910421 @default.
- W2253420912 hasConcept C2778163477 @default.
- W2253420912 hasConcept C2778718757 @default.
- W2253420912 hasConcept C2779222958 @default.
- W2253420912 hasConcept C4733338 @default.
- W2253420912 hasConcept C543025807 @default.
- W2253420912 hasConcept C553450214 @default.
- W2253420912 hasConcept C55493867 @default.
- W2253420912 hasConcept C85411794 @default.
- W2253420912 hasConcept C86803240 @default.
- W2253420912 hasConceptScore W2253420912C104317684 @default.
- W2253420912 hasConceptScore W2253420912C143065580 @default.
- W2253420912 hasConceptScore W2253420912C150194340 @default.
- W2253420912 hasConceptScore W2253420912C165864922 @default.
- W2253420912 hasConceptScore W2253420912C185592680 @default.
- W2253420912 hasConceptScore W2253420912C19038510 @default.
- W2253420912 hasConceptScore W2253420912C2776703722 @default.
- W2253420912 hasConceptScore W2253420912C2777129432 @default.
- W2253420912 hasConceptScore W2253420912C2777576037 @default.
- W2253420912 hasConceptScore W2253420912C2777910421 @default.
- W2253420912 hasConceptScore W2253420912C2778163477 @default.
- W2253420912 hasConceptScore W2253420912C2778718757 @default.
- W2253420912 hasConceptScore W2253420912C2779222958 @default.
- W2253420912 hasConceptScore W2253420912C4733338 @default.
- W2253420912 hasConceptScore W2253420912C543025807 @default.
- W2253420912 hasConceptScore W2253420912C553450214 @default.
- W2253420912 hasConceptScore W2253420912C55493867 @default.
- W2253420912 hasConceptScore W2253420912C85411794 @default.
- W2253420912 hasConceptScore W2253420912C86803240 @default.
- W2253420912 hasIssue "S1" @default.
- W2253420912 hasLocation W22534209121 @default.
- W2253420912 hasOpenAccess W2253420912 @default.
- W2253420912 hasPrimaryLocation W22534209121 @default.
- W2253420912 hasRelatedWork W1483218645 @default.
- W2253420912 hasRelatedWork W1828746466 @default.
- W2253420912 hasRelatedWork W1999771206 @default.
- W2253420912 hasRelatedWork W1999916089 @default.
- W2253420912 hasRelatedWork W2020912981 @default.
- W2253420912 hasRelatedWork W2058655151 @default.
- W2253420912 hasRelatedWork W2063803644 @default.
- W2253420912 hasRelatedWork W2119020076 @default.
- W2253420912 hasRelatedWork W2256689951 @default.
- W2253420912 hasRelatedWork W2528183312 @default.
- W2253420912 hasVolume "22" @default.
- W2253420912 isParatext "false" @default.
- W2253420912 isRetracted "false" @default.
- W2253420912 magId "2253420912" @default.
- W2253420912 workType "article" @default.