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- W2253466818 abstract "The discovery and the formation of nitric oxide from L-arginine opened a new field of research. The molecule nitric oxide (˙NO; nitrogen monoxide), known in biochemical and biomedical circles, serves as a messenger by binding to the heme of guanylate cyclase and, indirectly, as a cytotoxic agnet. Peroxynitrite in neutral solution is a powerful oxidant, oxidizing thiols such as mechionine, nitrating tyrosing residues, nitrating and oxidizing guanosine, initiating lipid peroxidation, and cleaving DNA. The primary determinants of how nitric oxide (˙NO) affects biological systems centers on its chemistry. Because the chemistry of ˙NO in biological system is extensive and complex. The chemical biology of NO provides a framework of relevant chemical reactions and provides a perspective that hopefully will insight into understanding the functions of ˙NO. This review discusses various aspects of the chemical biology of nitric oxide relating to biological molecules such as guanylate cyclase, cytochrome P450, nitric oxide synthase, catalase, and DNA and explores the potential roles of nitric oxide in different biological events." @default.
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- W2253466818 date "1999-12-01" @default.
- W2253466818 modified "2023-09-24" @default.
- W2253466818 title "Oxidative Chemistry and Chemical Biology of Superoxide, Nitric Oxide and Peroxynitrite" @default.
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