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• W2253473131 startingPage "305" @default.
• W2253473131 abstract "Purpose To characterize and T 1 relaxation time response to a wide spectrum of gas challenges in extracranial tissues of healthy rats. Materials and Methods A range of graded gas mixtures (hyperoxia, hypercapnia, hypoxia, and hypercapnic hypoxia) were delivered through a controlled gas‐mixing circuit to mechanically ventilated and intubated rats. Quantitative magnetic resonance imaging (MRI) was performed on a 3T clinical scanner; and T 1 maps were computed to determine tissue response in the liver, kidney cortex, and paraspinal muscles. Heart rate and blood oxygen saturation (SaO 2 ) were measured through a rodent oximeter and physiological monitor. Results decreases consistent with lowered SaO 2 measurements were observed for hypercapnia and hypoxia, but decreases were significant only in liver and kidney cortex ( P < 0.05) for >10% CO 2 and <15% O 2 , with the new gas stimulus, hypercapnic hypoxia, producing the greatest decrease. Hyperoxia‐related increases were accompanied by negligible increases in SaO 2 . T 1 generally increased, if at all, in the liver and decreased in the kidney. Significance was observed ( P < 0.05) only in kidney for >90% O 2 and >5% CO 2 . Conclusion and T 1 provide complementary roles for evaluating extracranial tissue response to a broad range of gas challenges. Based on both measured and known physiological responses, our results are consistent with as a sensitive marker of blood oxygen saturation and T 1 as a weak marker of blood volume changes. J. Magn. Reson. Imaging 2016;44:305–316." @default.
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• W2253473131 date "2016-02-13" @default.
• W2253473131 modified "2023-10-16" @default.
• W2253473131 title "T2* and T₁assessment of abdominal tissue response to graded hypoxia and hypercapnia using a controlled gas mixing circuit for small animals" @default.
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• W2253473131 doi "https://doi.org/10.1002/jmri.25169" @default.
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