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• W2253491153 abstract "Dietary copper deficiency significantly attenuates nitric oxide (NO)-mediated vascular smooth muscle relaxation and vasodilation. There is evidence for both increased inactivation of the NO radical by superoxide anion, and oxidative damage to the endothelium where NO is produced. The current study was designed to examine the NO synthetic pathway in the endothelium during copper deficiency. Male weanling rats were fed a copper-adequate (CuA, 6.4 mg Cu/kg diet) or copper-deficient (CuD, 0.4 mg Cu/kg diet) diet for four weeks. Cremasteric arterioles (-100μm diameter) were isolated and used for the experiments. Western blot analysis of the arteriole endothelial nitric oxide synthase (eNOS) concentration did not show a difference between dietary groups. Acetylcholine (Ach)-induced vasodilation was significantly reduced in the CuD group both before and after pretreatment with the eNOS substrate L-arginine. Endothelial intracellular calcium ([Ca2+]i) stimulated by 10−6M Ach was significantly inhibited in the arterioles from CuD rats. Coincident with the inhibition of [Ca2+]i and vasodilation was a depression of vascular Cu/Zn-SOD activity and an increase in plasma peroxynitritc activity. These data suggest that endothelial Ca2+ signaling and agonist-stimulated NO-mediated vascular dilation are likely reduced by increased oxidative damage in copper-deficient rats." @default.
• W2253491153 created "2016-06-24" @default.
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• W2253491153 date "2000-01-01" @default.
• W2253491153 modified "2023-09-25" @default.
• W2253491153 title "Endothelial Cell Calcium Mobilization to Acetylcholine is Attenuated in Copper-Deficient Rats" @default.
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• W2253491153 doi "https://doi.org/10.3109/10623320009072203" @default.
• W2253491153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10865936" @default.
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