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- W2253695417 abstract "The ability to reprogram adult mammalian somatic cells to a pluripotent state has proven to be a paradigm shifting discovery.1–3 In 2007, this reprogramming technology was translated to the engineering of human-induced pluripotent stem cells (hiPSCs) using skin fibroblasts by both the Yamanaka (transduction of c-Myc, Oct3/4, SOX2, and Klf4) and Thomson (transduction of Oct3/4, SOX2, Nanog, and Lin28) laboratories.2,3 Importantly, human donors could be fully phenotyped, and their hiPSCs, which retain their genetic blueprint, could be isolated and used to study human disease mechanisms in vitro.4 Given the potential use of these cells in understanding and treating disease, Feaster et al, in this issue of Circulation Research, optimize the culture conditions to promote the differentiation of hiPSC-derived cardiomyocytes.Article, see p 995 Our current understanding of the mechanisms that govern heart development and the pathophysiology of cardiovascular diseases have emerged primarily from genetic research models, such as the mouse and zebrafish. These genetic animal models, however, are limited in their ability to recapitulate the phenotype of patients with cardiovascular disease. Therefore, efforts in the past focused on the isolation of adult human cardiomyocytes from either an endomyocardial biopsy or from a surgical or pathological specimen. The yield from these samples was low, and the ability to obtain tissue from normal subjects was limited and not without risk.Novel insights into cardiogenesis, gained from the study of embryonic stem cells, have been instrumental …" @default.
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- W2253695417 date "2015-12-04" @default.
- W2253695417 modified "2023-09-26" @default.
- W2253695417 title "Go to the Mattresses" @default.
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- W2253695417 doi "https://doi.org/10.1161/circresaha.115.307794" @default.
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