FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2253704338> ?p ?o ?g. }

• W2253704338 abstract "Background and Purpose: Thromboxane A2 (TXA2) receptors (TP) interact with the ligand TXA2 to induce platelet aggregation and regulate hemostasis. Recently TP-mediated signaling has been suggested to function in multiple cell types in the brain. In this report, we aim to study the expression and physiological role of TP in microglia, in particular after brain ischemia. Methods: Ischemic brain sections were analyzed for TP expression. Microglial cell line and primary microglia were cultured, or neuronal cell line co-culture system was used to determine the TP mediated signaling in inflammation and microglia activation. Results: We found that the TP level was significantly increased in ipsilateral mouse brain tissue at 24 h after ischemia-reperfusion, which was also found to partly co-localize with CD11b, a marker for microglial and infiltrated monocyte/macrophage, in peri-infarct area. Immunofluorescence staining of primary microglia and microglial cell line BV2 revealed the predominant membrane distribution of TP. Conditioned culture media from TP agonist U46619-treated BV2 cells decreased neuronal SH-SY5Y cell viability and induced apoptotic morphological changes. Furthermore, U46619 enhanced IL-1β, IL-6 and iNOS mRNA expression as well as IL-1β and NO releases in BV2 cells or primary microglia. Such stimulation could be attenuated by TP antagonist SQ29548 or MEK inhibitor U0126. The dose- and time-dependent extracellular-signal-regulated kinase (ERK) phosphorylation induced by U46619 further demonstrated ERK signaling-mediated microglia activation by TP agonist. Conclusions: This study has shown a novel role of TP in microglia activation via the ERK signaling pathway, which provides insights for the management of neuroinflammation in diseases like cerebral infarction." @default.
• W2253704338 created "2016-06-24" @default.
• W2253704338 creator A5004600709 @default.
• W2253704338 creator A5008008825 @default.
• W2253704338 creator A5018921514 @default.
• W2253704338 creator A5036365256 @default.
• W2253704338 creator A5056581388 @default.
• W2253704338 creator A5062047914 @default.
• W2253704338 creator A5066123521 @default.
• W2253704338 creator A5083812342 @default.
• W2253704338 date "2016-01-29" @default.
• W2253704338 modified "2023-09-23" @default.
• W2253704338 title "Thromboxane A2 Receptor Stimulation Enhances Microglial Interleukin-1β and NO Biosynthesis Mediated by the Activation of ERK Pathway" @default.
• W2253704338 cites W1498166809 @default.
• W2253704338 cites W1535712295 @default.
• W2253704338 cites W1595898720 @default.
• W2253704338 cites W1597473130 @default.
• W2253704338 cites W1793993480 @default.
• W2253704338 cites W1968026156 @default.
• W2253704338 cites W1983615367 @default.
• W2253704338 cites W1984715375 @default.
• W2253704338 cites W1985780036 @default.
• W2253704338 cites W1988642438 @default.
• W2253704338 cites W2001991697 @default.
• W2253704338 cites W2004741531 @default.
• W2253704338 cites W2005470401 @default.
• W2253704338 cites W2009323806 @default.
• W2253704338 cites W2011955349 @default.
• W2253704338 cites W2026489774 @default.
• W2253704338 cites W2028383092 @default.
• W2253704338 cites W2030009873 @default.
• W2253704338 cites W2030087792 @default.
• W2253704338 cites W2041981966 @default.
• W2253704338 cites W2043033966 @default.
• W2253704338 cites W2048009051 @default.
• W2253704338 cites W2051138947 @default.
• W2253704338 cites W2057951356 @default.
• W2253704338 cites W2058821838 @default.
• W2253704338 cites W2063541896 @default.
• W2253704338 cites W2063956233 @default.
• W2253704338 cites W2068477112 @default.
• W2253704338 cites W2074298460 @default.
• W2253704338 cites W2075454634 @default.
• W2253704338 cites W2079858540 @default.
• W2253704338 cites W2087265687 @default.
• W2253704338 cites W2088483797 @default.
• W2253704338 cites W2091347541 @default.
• W2253704338 cites W2092296830 @default.
• W2253704338 cites W2092873641 @default.
• W2253704338 cites W2098372009 @default.
• W2253704338 cites W2101866426 @default.
• W2253704338 cites W2104378795 @default.
• W2253704338 cites W2111354263 @default.
• W2253704338 cites W2113458482 @default.
• W2253704338 cites W2115262431 @default.
• W2253704338 cites W2118385827 @default.
• W2253704338 cites W2128091651 @default.
• W2253704338 cites W2131939356 @default.
• W2253704338 cites W2137232579 @default.
• W2253704338 cites W2138312308 @default.
• W2253704338 cites W2144531458 @default.
• W2253704338 cites W2150842829 @default.
• W2253704338 cites W2261115509 @default.
• W2253704338 cites W2404728486 @default.
• W2253704338 cites W2405283859 @default.
• W2253704338 cites W2411451432 @default.
• W2253704338 cites W3141552805 @default.
• W2253704338 doi "https://doi.org/10.3389/fnagi.2016.00008" @default.
• W2253704338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4731520" @default.
• W2253704338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26858639" @default.
• W2253704338 hasPublicationYear "2016" @default.
• W2253704338 type Work @default.
• W2253704338 sameAs 2253704338 @default.
• W2253704338 citedByCount "22" @default.
• W2253704338 countsByYear W22537043382016 @default.
• W2253704338 countsByYear W22537043382017 @default.
• W2253704338 countsByYear W22537043382018 @default.
• W2253704338 countsByYear W22537043382019 @default.
• W2253704338 countsByYear W22537043382020 @default.
• W2253704338 countsByYear W22537043382021 @default.
• W2253704338 countsByYear W22537043382022 @default.
• W2253704338 crossrefType "journal-article" @default.
• W2253704338 hasAuthorship W2253704338A5004600709 @default.
• W2253704338 hasAuthorship W2253704338A5008008825 @default.
• W2253704338 hasAuthorship W2253704338A5018921514 @default.
• W2253704338 hasAuthorship W2253704338A5036365256 @default.
• W2253704338 hasAuthorship W2253704338A5056581388 @default.
• W2253704338 hasAuthorship W2253704338A5062047914 @default.
• W2253704338 hasAuthorship W2253704338A5066123521 @default.
• W2253704338 hasAuthorship W2253704338A5083812342 @default.
• W2253704338 hasBestOaLocation W22537043381 @default.
• W2253704338 hasConcept C126322002 @default.
• W2253704338 hasConcept C134018914 @default.
• W2253704338 hasConcept C1491633281 @default.
• W2253704338 hasConcept C170493617 @default.
• W2253704338 hasConcept C171779818 @default.
• W2253704338 hasConcept C185592680 @default.
• W2253704338 hasConcept C203014093 @default.
• W2253704338 hasConcept C24998067 @default.
• W2253704338 hasConcept C2776914184 @default.

• next