FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2254084119> ?p ?o ?g. }

• W2254084119 abstract "Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder with core symptoms of atypical social interactions and repetitive behaviors. It has also been reported that individuals with ASD have difficulty with multisensory integration, and this may disrupt higher-order cognitive abilities such as learning and social communication. Impairments in the integration of sensory information could in turn reflect diminished cross-modal white matter connectivity. Moreover, the genetic contribution in ASD appears to be strong, with heritability estimates as high as 90%. However, no single gene has been identified, and over 1000 risk genes have been reported. One of these genes - contactin-associated-like-protein 2 (CNTNAP2) - was first associated with Specific Language Impairment, and more recently has been linked to ASD. CNTNAP2 encodes a cell adhesion protein regulating synaptic signal transmission. To better understand the behavioral and biological underlying mechanisms of ASD, a transgenic mouse model was created with a genetic knockout (KO) of the rodent homolog Cntnap2. Initial studies on this mouse revealed poor social interactions, behavioral perseveration, and reduced vocalizations-all strongly resembling human ASD symptoms. Cntnap2 KO mice also show abnormalities in myelin formation, consistent with a hypo-connectivity model of ASD. The current study was designed to further assess the behavioral phenotype of this mouse model, with a focus on learning and memory. Cntnap2 KO and wild-type mice were tested on a 4/8 radial arm water maze for 14 consecutive days. Error scores (total, working memory, reference memory, initial and repeated reference memory), latency and average turn angle were independently assessed using a 2×14 repeated measures ANOVA. Results showed that Cntnap2 KO mice exhibited significant deficits in working and reference memory during the acquisition period of the task. During the retention period (i.e., after asymptote in errors), Cntnap2 KO mice performed comparably to wild-type mice. These findings suggest that CNTNAP2 may influence the development of neural systems important to learning and cross-modal integration, and that disruption of this function could be associated with delayed learning in ASD." @default.
• W2254084119 created "2016-06-24" @default.
• W2254084119 creator A5016452429 @default.
• W2254084119 creator A5028626629 @default.
• W2254084119 creator A5045278236 @default.
• W2254084119 date "2016-04-01" @default.
• W2254084119 modified "2023-09-30" @default.
• W2254084119 title "Learning delays in a mouse model of Autism Spectrum Disorder" @default.
• W2254084119 cites W1759848617 @default.
• W2254084119 cites W1973574506 @default.
• W2254084119 cites W1976980285 @default.
• W2254084119 cites W1989563742 @default.
• W2254084119 cites W1993462172 @default.
• W2254084119 cites W1995809507 @default.
• W2254084119 cites W2004091189 @default.
• W2254084119 cites W2005428468 @default.
• W2254084119 cites W2015524830 @default.
• W2254084119 cites W2035361044 @default.
• W2254084119 cites W2048260661 @default.
• W2254084119 cites W2076406415 @default.
• W2254084119 cites W2096504331 @default.
• W2254084119 cites W2098251401 @default.
• W2254084119 cites W2099756187 @default.
• W2254084119 cites W2100242214 @default.
• W2254084119 cites W2122971055 @default.
• W2254084119 cites W2123739801 @default.
• W2254084119 cites W2126538155 @default.
• W2254084119 cites W2135802610 @default.
• W2254084119 cites W2141533663 @default.
• W2254084119 cites W2141805926 @default.
• W2254084119 cites W2143256436 @default.
• W2254084119 cites W2152704739 @default.
• W2254084119 cites W2159097812 @default.
• W2254084119 cites W2161984003 @default.
• W2254084119 cites W2162490007 @default.
• W2254084119 cites W2167868121 @default.
• W2254084119 cites W2422252795 @default.
• W2254084119 cites W4300998128 @default.
• W2254084119 doi "https://doi.org/10.1016/j.bbr.2016.02.006" @default.
• W2254084119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4896155" @default.
• W2254084119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26873041" @default.
• W2254084119 hasPublicationYear "2016" @default.
• W2254084119 type Work @default.
• W2254084119 sameAs 2254084119 @default.
• W2254084119 citedByCount "22" @default.
• W2254084119 countsByYear W22540841192017 @default.
• W2254084119 countsByYear W22540841192018 @default.
• W2254084119 countsByYear W22540841192019 @default.
• W2254084119 countsByYear W22540841192020 @default.
• W2254084119 countsByYear W22540841192022 @default.
• W2254084119 countsByYear W22540841192023 @default.
• W2254084119 crossrefType "journal-article" @default.
• W2254084119 hasAuthorship W2254084119A5016452429 @default.
• W2254084119 hasAuthorship W2254084119A5028626629 @default.
• W2254084119 hasAuthorship W2254084119A5045278236 @default.
• W2254084119 hasBestOaLocation W22540841191 @default.
• W2254084119 hasConcept C138496976 @default.
• W2254084119 hasConcept C15744967 @default.
• W2254084119 hasConcept C169760540 @default.
• W2254084119 hasConcept C169900460 @default.
• W2254084119 hasConcept C205778803 @default.
• W2254084119 hasConcept C2778538070 @default.
• W2254084119 hasConcept C2779388368 @default.
• W2254084119 hasConcept C2780769854 @default.
• W2254084119 hasConceptScore W2254084119C138496976 @default.
• W2254084119 hasConceptScore W2254084119C15744967 @default.
• W2254084119 hasConceptScore W2254084119C169760540 @default.
• W2254084119 hasConceptScore W2254084119C169900460 @default.
• W2254084119 hasConceptScore W2254084119C205778803 @default.
• W2254084119 hasConceptScore W2254084119C2778538070 @default.
• W2254084119 hasConceptScore W2254084119C2779388368 @default.
• W2254084119 hasConceptScore W2254084119C2780769854 @default.
• W2254084119 hasFunder F4320306076 @default.
• W2254084119 hasFunder F4320332161 @default.
• W2254084119 hasLocation W22540841191 @default.
• W2254084119 hasLocation W22540841192 @default.
• W2254084119 hasLocation W22540841193 @default.
• W2254084119 hasLocation W22540841194 @default.
• W2254084119 hasLocation W22540841195 @default.
• W2254084119 hasOpenAccess W2254084119 @default.
• W2254084119 hasPrimaryLocation W22540841191 @default.
• W2254084119 hasRelatedWork W136531487 @default.
• W2254084119 hasRelatedWork W1992587705 @default.
• W2254084119 hasRelatedWork W2022498096 @default.
• W2254084119 hasRelatedWork W2037553020 @default.
• W2254084119 hasRelatedWork W2039794349 @default.
• W2254084119 hasRelatedWork W2099756187 @default.
• W2254084119 hasRelatedWork W2118922889 @default.
• W2254084119 hasRelatedWork W2122971055 @default.
• W2254084119 hasRelatedWork W2126538155 @default.
• W2254084119 hasRelatedWork W2137065599 @default.
• W2254084119 hasRelatedWork W2150975118 @default.
• W2254084119 hasRelatedWork W2422252795 @default.
• W2254084119 hasRelatedWork W2579874156 @default.
• W2254084119 hasRelatedWork W2626605337 @default.
• W2254084119 hasRelatedWork W2901747261 @default.
• W2254084119 hasRelatedWork W2916237377 @default.
• W2254084119 hasRelatedWork W2966246125 @default.
• W2254084119 hasRelatedWork W2985038305 @default.
• W2254084119 hasRelatedWork W3018465724 @default.

• next