Matches in SemOpenAlex for { <https://semopenalex.org/work/W2254258889> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2254258889 endingPage "80" @default.
- W2254258889 startingPage "676" @default.
- W2254258889 abstract "Therapy for advanced non-small cell lung cancer (NSCLC) is very complex clinical problem. The optimal choice of therapy demands not only the analysis of data on clinical effectiveness, but also an assessment of cost-effectiveness of the applied drugs. The current options for first- or second/third-line of lung cancer treatment are tirosine kinase inhibitors (TKI)--gefitinib, erlotinib and afatinib. According to the received results TKI first-line therapy for NSCLC in patients with EGFR mutations is not only clinically effective but also is economically acceptable from a position of the Russian budgetary health care. TKI second-line therapy for NSCLC patients who fail first-line therapy also provides improvement of the quality of life and prolonged time to progression. Comparable clinical effectiveness and safety of erlotinib and gefitinib in patients with EGFR mutations allows making drug choice on the basis of regional price characteristics. Afatinib is highly effective both in the first- and in the second/third-line of therapy in patients with the most frequent mutations (a deletion in exon 19 or a point mutation L858R in exon 21) but first-line therapy demands an increase of financial expenses caused by substantial increase of time to progression and duration of therapy. Thus TKI therapy of both the first-, and second/third-line of patients with NSCLC with EGFR mutations is characterized by acceptable cost-effectiveness." @default.
- W2254258889 created "2016-06-24" @default.
- W2254258889 creator A5052975833 @default.
- W2254258889 creator A5083779689 @default.
- W2254258889 date "2015-01-01" @default.
- W2254258889 modified "2023-09-23" @default.
- W2254258889 title "[Gefitinib therapy in advanced non-small cell lung cancer in patients with EGFR mutations: cost-effectiveness analysis]." @default.
- W2254258889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26571844" @default.
- W2254258889 hasPublicationYear "2015" @default.
- W2254258889 type Work @default.
- W2254258889 sameAs 2254258889 @default.
- W2254258889 citedByCount "0" @default.
- W2254258889 crossrefType "journal-article" @default.
- W2254258889 hasAuthorship W2254258889A5052975833 @default.
- W2254258889 hasAuthorship W2254258889A5083779689 @default.
- W2254258889 hasConcept C121608353 @default.
- W2254258889 hasConcept C126322002 @default.
- W2254258889 hasConcept C143998085 @default.
- W2254258889 hasConcept C177713679 @default.
- W2254258889 hasConcept C2776256026 @default.
- W2254258889 hasConcept C2778087573 @default.
- W2254258889 hasConcept C2779438470 @default.
- W2254258889 hasConcept C2780580887 @default.
- W2254258889 hasConcept C2780586478 @default.
- W2254258889 hasConcept C2781230642 @default.
- W2254258889 hasConcept C71924100 @default.
- W2254258889 hasConceptScore W2254258889C121608353 @default.
- W2254258889 hasConceptScore W2254258889C126322002 @default.
- W2254258889 hasConceptScore W2254258889C143998085 @default.
- W2254258889 hasConceptScore W2254258889C177713679 @default.
- W2254258889 hasConceptScore W2254258889C2776256026 @default.
- W2254258889 hasConceptScore W2254258889C2778087573 @default.
- W2254258889 hasConceptScore W2254258889C2779438470 @default.
- W2254258889 hasConceptScore W2254258889C2780580887 @default.
- W2254258889 hasConceptScore W2254258889C2780586478 @default.
- W2254258889 hasConceptScore W2254258889C2781230642 @default.
- W2254258889 hasConceptScore W2254258889C71924100 @default.
- W2254258889 hasIssue "4" @default.
- W2254258889 hasLocation W22542588891 @default.
- W2254258889 hasOpenAccess W2254258889 @default.
- W2254258889 hasPrimaryLocation W22542588891 @default.
- W2254258889 hasRelatedWork W2049303357 @default.
- W2254258889 hasRelatedWork W2060263774 @default.
- W2254258889 hasRelatedWork W2075462316 @default.
- W2254258889 hasRelatedWork W2079547562 @default.
- W2254258889 hasRelatedWork W2135761436 @default.
- W2254258889 hasRelatedWork W2169921827 @default.
- W2254258889 hasRelatedWork W2261901203 @default.
- W2254258889 hasRelatedWork W2888534976 @default.
- W2254258889 hasRelatedWork W2979585789 @default.
- W2254258889 hasRelatedWork W3175282903 @default.
- W2254258889 hasVolume "61" @default.
- W2254258889 isParatext "false" @default.
- W2254258889 isRetracted "false" @default.
- W2254258889 magId "2254258889" @default.
- W2254258889 workType "article" @default.