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• W2254280466 abstract "Parkinson’s disease (PD) is caused by the loss of dopaminergic neurons of substantia nigra. The motor symptoms of PD (tremor, bradykinesia, akinesia, rigidity, and disturbances of gait and posture) are due to the progressive loss of these dopaminergic neurons that project to the striatum. The most prevalent therapy is oral levodopa (in combination with compounds that enhance its bioavailability), but levodopa is not efficacious after several years of treatment. An alternative therapy to levodopa is the use of intrastriatal grafts of cells capable of ameliorating functional deficits of PD. Since the 1980s, grafting procedures have been extensively tested in animal models of PD, before their clinical application [1–9]. Transplantation is considered as a promising treatment for human Parkinson’s disease, and grafting procedures performed as clinical therapy for PD could be classified in twomain groups: (i) grafts devoted to the restoration of the dopamine levels in the denervated striatum by using dopamine-secreting cells (i.e., fetal or embryonic dopaminergic cells, engineered dopaminergic stem-derived cells, retinal pigment epithelial cells, etc.), or cultured sympathetic neurons that convert exogenous levodopa in dopamine, and (ii) dopaminotrophic grafting procedures directed to provide a trophic support for the remaining host nigrostriatal dopaminergic neurons, in order to stop neuronal death or to restore the striatal dopaminergic circuit. Another plausible form of cell therapy is the activation of pre-existing neuronal precursors located in neurogenic centers that could migrate and differentiate to replace destroyed cells in some parts of the brain. This possibility is speculative at present and based solely on preliminary experimental obseravtions. It is reasonable to think that, since levodopa significantly ameliorate functional deficits in PD, grafting dopamine-secreting cells for providing a constant" @default.
• W2254280466 created "2016-06-24" @default.
• W2254280466 creator A5000797095 @default.
• W2254280466 creator A5030595614 @default.
• W2254280466 date "2008-12-31" @default.
• W2254280466 modified "2023-10-04" @default.
• W2254280466 title "Cell-Based Replacement Therapies for Parkinson’s Disease" @default.
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