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- W225432889 endingPage "e0126535" @default.
- W225432889 startingPage "e0126535" @default.
- W225432889 abstract "miRNAs play a central role in numerous pathologies including multiple cancer types. miR-191 has predominantly been studied as an oncogene, but the role of miR-191 in the proliferation of primary cells is not well characterized, and the miR-191 targetome has not been experimentally profiled. Here we utilized RNA induced silencing complex immunoprecipitations as well as gene expression profiling to construct a genome wide miR-191 target profile. We show that miR-191 represses proliferation in primary human fibroblasts, identify multiple proto-oncogenes as novel miR-191 targets, including CDK9, NOTCH2, and RPS6KA3, and present evidence that miR-191 extensively mediates target expression through coding sequence (CDS) pairing. Our results provide a comprehensive genome wide miR-191 target profile, and demonstrate miR-191's regulation of primary human fibroblast proliferation." @default.
- W225432889 created "2016-06-24" @default.
- W225432889 creator A5014470919 @default.
- W225432889 creator A5044599919 @default.
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- W225432889 date "2015-05-20" @default.
- W225432889 modified "2023-10-11" @default.
- W225432889 title "MiR-191 Regulates Primary Human Fibroblast Proliferation and Directly Targets Multiple Oncogenes" @default.
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- W225432889 doi "https://doi.org/10.1371/journal.pone.0126535" @default.
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