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- W2254432763 abstract "Patients with chronic obstructive pulmonary disease may have recurrent bouts of ventilatory failure. It has previously been shown that increase in metabolic rate, decrease in minute ventilation, and increase in physiologic dead space, either singly or in combination, are responsible for these episodes of increased carbon dioxide retention (I). The increased metabolic rate may be caused either by increased work of breathing or by agitation, but it is not generally due to fever. The decreased minute ventilation may be the result of increased severity of mechanical disturbance of the lungs or of respiratory depression by hypercapnea or medication. Increased dead space ventilation results from the shallow rapid breathing that is common in this condition. In addition, uneven ventilation, partially due to the rapid respiratory rate (2-4), leads to increase of the physiologic dead space. Intermittent positive pressure breathing (IPPB) has been used to decrease hypercapnea in patients with chronic obstructive pulmonary disease. Increased tidal volume with decreased respiratory rate, especially when associated with an increased minute ventilation, should result in increased alveolar ventilation. A person who is completely relaxed and allows the IPPB to inflate his lungs should benefit by decreased work of breathing, and his metabolic rate should be reduced (5). Beneficial results have been claimed by several investigators (5-8)," @default.
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- W2254432763 date "1965-12-01" @default.
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- W2254432763 title "The effect of intermittent positive pressure breathing (IPPB) in acute ventilatory failure." @default.
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- W2254432763 doi "https://doi.org/10.1164/arrd.1965.92.6p1.885" @default.
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