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- W2254508519 abstract "The weaver mouse, is a phenocopy of Parkinson's disease (PD) in which dopaminergic neurons degenerate gradually during development, reaching at P21 a neurodegeneration of 55%. Thus, the weaver mouse constitutes an appropriate in vivo PD model for investigating the effect of neuroprotective agents. In the present study, long-term treatment (from P1 to P21) with 17β-estradiol (17β-estradiol) significantly protected the dopaminergic neurons in the substantia nigra (SN) of weaver mouse by 54%, as was detected by immunohistochemical experiments, using the specific antibody against tyrosine hydroxylase (TH). This dopaminergic neuroprotection is in line with our biochemical results showing that 17β-estradiol treatment significantly decreased the high lipid peroxidation levels seen in the SN of weaver mouse, indicating high oxidative stress. Interestingly, co-administration of 17β-estradiol with N-acetylcysteine (NAC, precursor molecule of glutathione (GSH)) further significantly increased the survival of dopaminergic neurons in the SN (by 85%), with a parallel further decrease of lipid peroxidation to normal levels. Our results show the in vivo neuroprotective effect of 17β-estradiol, which is strongly enhanced by co administration of NAC, indicating a strong synergistic effect of the two drugs. Furthermore, the main mechanism underlying this neuroprotective action seems to be the reversal of the oxidative stress shown by the high peroxidation levels. These results could be of clinical relevance since both drugs are already used separately in the clinic, 17β-estradiol for treatment of PD and NAC as a mucolytic agent and for the treatment of several disorders." @default.
- W2254508519 created "2016-06-24" @default.
- W2254508519 creator A5010206684 @default.
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- W2254508519 creator A5083040062 @default.
- W2254508519 date "2016-04-01" @default.
- W2254508519 modified "2023-09-27" @default.
- W2254508519 title "17β-Estradiol/N-acetylcysteine interaction enhances the neuroprotective effect on dopaminergic neurons in the weaver model of dopamine deficiency" @default.
- W2254508519 cites W1539334271 @default.
- W2254508519 cites W1588992136 @default.
- W2254508519 cites W1590457525 @default.
- W2254508519 cites W1590877183 @default.
- W2254508519 cites W1818239859 @default.
- W2254508519 cites W1887527925 @default.
- W2254508519 cites W1889609763 @default.
- W2254508519 cites W1973740717 @default.
- W2254508519 cites W1975774284 @default.
- W2254508519 cites W1977571517 @default.
- W2254508519 cites W1979867396 @default.
- W2254508519 cites W1988172735 @default.
- W2254508519 cites W1989498664 @default.
- W2254508519 cites W1993241967 @default.
- W2254508519 cites W1993416074 @default.
- W2254508519 cites W1994044142 @default.
- W2254508519 cites W1994967294 @default.
- W2254508519 cites W1994990146 @default.
- W2254508519 cites W1998396025 @default.
- W2254508519 cites W2001089271 @default.
- W2254508519 cites W2001236923 @default.
- W2254508519 cites W2004611188 @default.
- W2254508519 cites W2005137243 @default.
- W2254508519 cites W2005907346 @default.
- W2254508519 cites W2006376003 @default.
- W2254508519 cites W2007263918 @default.
- W2254508519 cites W2008885463 @default.
- W2254508519 cites W2012080584 @default.
- W2254508519 cites W2015555425 @default.
- W2254508519 cites W2018651845 @default.
- W2254508519 cites W2023316858 @default.
- W2254508519 cites W2023404393 @default.
- W2254508519 cites W2025595769 @default.
- W2254508519 cites W2027548273 @default.
- W2254508519 cites W2029740091 @default.
- W2254508519 cites W2029879331 @default.
- W2254508519 cites W2030907959 @default.
- W2254508519 cites W2032028601 @default.
- W2254508519 cites W2032562748 @default.
- W2254508519 cites W2032840849 @default.
- W2254508519 cites W2035034074 @default.
- W2254508519 cites W2036625562 @default.
- W2254508519 cites W2038730603 @default.
- W2254508519 cites W2042871946 @default.
- W2254508519 cites W2043348076 @default.
- W2254508519 cites W2044192933 @default.
- W2254508519 cites W2045616163 @default.
- W2254508519 cites W2047263160 @default.
- W2254508519 cites W2048665844 @default.
- W2254508519 cites W2048897966 @default.
- W2254508519 cites W2049111053 @default.
- W2254508519 cites W2050034414 @default.
- W2254508519 cites W2051256200 @default.
- W2254508519 cites W2052004566 @default.
- W2254508519 cites W2052595266 @default.
- W2254508519 cites W2054120163 @default.
- W2254508519 cites W2055299738 @default.
- W2254508519 cites W2060838923 @default.
- W2254508519 cites W2063165012 @default.
- W2254508519 cites W2064499965 @default.
- W2254508519 cites W2065632340 @default.
- W2254508519 cites W2065809073 @default.
- W2254508519 cites W2068015577 @default.
- W2254508519 cites W2072584061 @default.
- W2254508519 cites W2073777605 @default.
- W2254508519 cites W2073803664 @default.
- W2254508519 cites W2079000436 @default.
- W2254508519 cites W2079726434 @default.
- W2254508519 cites W2081412929 @default.
- W2254508519 cites W2082599180 @default.
- W2254508519 cites W2085227738 @default.
- W2254508519 cites W2086396014 @default.
- W2254508519 cites W2088318694 @default.
- W2254508519 cites W2088529700 @default.
- W2254508519 cites W2088664861 @default.
- W2254508519 cites W2090245298 @default.
- W2254508519 cites W2091456465 @default.
- W2254508519 cites W2092312975 @default.
- W2254508519 cites W2102314603 @default.
- W2254508519 cites W2106557112 @default.
- W2254508519 cites W2108238189 @default.
- W2254508519 cites W2111398489 @default.
- W2254508519 cites W2111464898 @default.
- W2254508519 cites W2112765817 @default.