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- W2254554296 abstract "The roles of nicotine on Ca 2+ oscillations [intracellular Ca 2+ ([Ca 2+ ] i ) oscillation] in rat primary cultured cortical neurons were studied. The spontaneous [Ca 2+ ] i oscillations (SCO) were recorded in a portion of the neurons (65%) cultured for 7–10 days in vitro. Application of nicotine enhanced [Ca 2+ ] i oscillation frequency and amplitude, which were reduced by the selective α 4 β 2 -nicotinic acetylcholine receptors (nAChRs) antagonist dihydro-β-erythroidine (DHβE) hydrobromide, and the selective α 7 -nAChRs antagonist methyllycaconitine citrate (MLA, 20 nM). DHβE reduced SCO frequency and prevented the nicotinic increase in the frequency. DHβE somewhat enhanced SCO amplitude and prevented nicotinic increase in the amplitude. MLA (20 nM) itself reduced SCO frequency without affecting the amplitude but blocked nicotinic increase in [Ca 2+ ] i oscillation frequency and amplitude. Furthermore, coadministration of both α 4 β 2 - and α 7 -nAChRs antagonists completely prevented nicotinic increment in [Ca 2+ ] i oscillation frequency and amplitude. Thus, our results indicate that both α 4 β 2 - and α 7 -nAChRs mediated nicotine-induced [Ca 2+ ] i oscillations, and two nAChR subtypes differentially regulated SCO." @default.
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- W2254554296 date "2016-05-01" @default.
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- W2254554296 title "Nicotinic modulation of Ca2+ oscillations in rat cortical neurons in vitro" @default.
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- W2254554296 doi "https://doi.org/10.1152/ajpcell.00197.2015" @default.
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