FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2254718306> ?p ?o ?g. }

• W2254718306 endingPage "e0143738" @default.
• W2254718306 startingPage "e0143738" @default.
• W2254718306 abstract "Malaria is a significant global health issue, with nearly 200 million cases in 2013 alone. Parasites obtain folate from the host or synthesize it de novo. Folate consumption has increased in many populations, prompting concerns regarding potential deleterious consequences of higher intake. The impact of high dietary folate on the host's immune function and response to malaria has not been examined. Our goal was to determine whether high dietary folate would affect response to malarial infection in a murine model of cerebral malaria. Mice were fed control diets (CD, recommended folate level for rodents) or folic acid-supplemented diets (FASD, 10x recommended level) for 5 weeks before infection with Plasmodium berghei ANKA. Survival, parasitemia, numbers of immune cells and other infection parameters were assessed. FASD mice had reduced survival (p<0.01, Cox proportional hazards) and higher parasitemia (p< 0.01, joint model of parasitemia and survival) compared with CD mice. FASD mice had lower numbers of splenocytes, total T cells, and lower numbers of specific T and NK cell sub-populations, compared with CD mice (p<0.05, linear mixed effects). Increased brain TNFα immunoreactive protein (p<0.01, t-test) and increased liver Abca1 mRNA (p<0.01, t-test), a modulator of TNFα, were observed in FASD mice; these variables correlated positively (rs = 0.63, p = 0.01). Bcl-xl/Bak mRNA was increased in liver of FASD mice (p<0.01, t-test), suggesting reduced apoptotic potential. We conclude that high dietary folate increases parasite replication, disturbs the immune response and reduces resistance to malaria in mice. These findings have relevance for malaria-endemic regions, when considering anti-folate anti-malarials, food fortification or vitamin supplementation programs." @default.
• W2254718306 created "2016-06-24" @default.
• W2254718306 creator A5008312992 @default.
• W2254718306 creator A5042816112 @default.
• W2254718306 creator A5044726994 @default.
• W2254718306 creator A5070647685 @default.
• W2254718306 date "2015-11-24" @default.
• W2254718306 modified "2023-09-25" @default.
• W2254718306 title "High Dietary Folate in Mice Alters Immune Response and Reduces Survival after Malarial Infection" @default.
• W2254718306 cites W12995195 @default.
• W2254718306 cites W1506911784 @default.
• W2254718306 cites W1544121010 @default.
• W2254718306 cites W1556254857 @default.
• W2254718306 cites W1570622790 @default.
• W2254718306 cites W1577577364 @default.
• W2254718306 cites W1579883177 @default.
• W2254718306 cites W1922615383 @default.
• W2254718306 cites W1966554631 @default.
• W2254718306 cites W1970608967 @default.
• W2254718306 cites W1977569620 @default.
• W2254718306 cites W1980672627 @default.
• W2254718306 cites W1986271253 @default.
• W2254718306 cites W1992496526 @default.
• W2254718306 cites W1998382042 @default.
• W2254718306 cites W1999177573 @default.
• W2254718306 cites W2013885224 @default.
• W2254718306 cites W2022636507 @default.
• W2254718306 cites W2023811069 @default.
• W2254718306 cites W2032019813 @default.
• W2254718306 cites W2035779622 @default.
• W2254718306 cites W2047004099 @default.
• W2254718306 cites W2049726050 @default.
• W2254718306 cites W2053684700 @default.
• W2254718306 cites W2059257421 @default.
• W2254718306 cites W2068045945 @default.
• W2254718306 cites W2073029385 @default.
• W2254718306 cites W2078725156 @default.
• W2254718306 cites W2083508061 @default.
• W2254718306 cites W2084217066 @default.
• W2254718306 cites W2085077927 @default.
• W2254718306 cites W2095829821 @default.
• W2254718306 cites W2097452962 @default.
• W2254718306 cites W2099536293 @default.
• W2254718306 cites W2103538230 @default.
• W2254718306 cites W2104004482 @default.
• W2254718306 cites W2117147047 @default.
• W2254718306 cites W2119626572 @default.
• W2254718306 cites W2120600865 @default.
• W2254718306 cites W2121452230 @default.
• W2254718306 cites W2125048345 @default.
• W2254718306 cites W2125086149 @default.
• W2254718306 cites W2127935571 @default.
• W2254718306 cites W2129239355 @default.
• W2254718306 cites W2132726154 @default.
• W2254718306 cites W2134635143 @default.
• W2254718306 cites W2134883341 @default.
• W2254718306 cites W2135016146 @default.
• W2254718306 cites W2136019630 @default.
• W2254718306 cites W2136865578 @default.
• W2254718306 cites W2140483277 @default.
• W2254718306 cites W2140823590 @default.
• W2254718306 cites W2144849875 @default.
• W2254718306 cites W2147007502 @default.
• W2254718306 cites W2148095569 @default.
• W2254718306 cites W2155748247 @default.
• W2254718306 cites W2167612600 @default.
• W2254718306 cites W2169999775 @default.
• W2254718306 cites W2300405932 @default.
• W2254718306 cites W2461588752 @default.
• W2254718306 cites W4230929420 @default.
• W2254718306 cites W4244100620 @default.
• W2254718306 cites W4298129233 @default.
• W2254718306 doi "https://doi.org/10.1371/journal.pone.0143738" @default.
• W2254718306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4658061" @default.
• W2254718306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26599510" @default.
• W2254718306 hasPublicationYear "2015" @default.
• W2254718306 type Work @default.
• W2254718306 sameAs 2254718306 @default.
• W2254718306 citedByCount "16" @default.
• W2254718306 countsByYear W22547183062016 @default.
• W2254718306 countsByYear W22547183062017 @default.
• W2254718306 countsByYear W22547183062018 @default.
• W2254718306 countsByYear W22547183062019 @default.
• W2254718306 countsByYear W22547183062020 @default.
• W2254718306 countsByYear W22547183062021 @default.
• W2254718306 countsByYear W22547183062022 @default.
• W2254718306 countsByYear W22547183062023 @default.
• W2254718306 crossrefType "journal-article" @default.
• W2254718306 hasAuthorship W2254718306A5008312992 @default.
• W2254718306 hasAuthorship W2254718306A5042816112 @default.
• W2254718306 hasAuthorship W2254718306A5044726994 @default.
• W2254718306 hasAuthorship W2254718306A5070647685 @default.
• W2254718306 hasBestOaLocation W22547183061 @default.
• W2254718306 hasConcept C203014093 @default.
• W2254718306 hasConcept C2775867548 @default.
• W2254718306 hasConcept C2777237215 @default.
• W2254718306 hasConcept C2778048844 @default.
• W2254718306 hasConcept C2778371730 @default.

• next