FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2254879660> ?p ?o ?g. }

• W2254879660 abstract "Abstract Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit + cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. Here we provide further insights into the nature of cardiac c-kit + cells. By targeting the c-kit locus with multiple reporter genes in mice, we find that c-kit expression rarely co-localizes with the expression of the cardiac progenitor and myogenic marker Nkx2.5 , or that of the myocardial marker, cardiac troponin T (cTnT) . Instead, c-kit predominantly labels a cardiac endothelial cell population in developing and adult hearts. After acute cardiac injury, c-kit + cells retain their endothelial identity and do not become myogenic progenitors or cardiomyocytes. Thus, our work strongly suggests that c-kit + cells in the murine heart are endothelial cells and not CSCs." @default.
• W2254879660 created "2016-06-24" @default.
• W2254879660 creator A5000696964 @default.
• W2254879660 creator A5011123465 @default.
• W2254879660 creator A5018068367 @default.
• W2254879660 creator A5029133469 @default.
• W2254879660 creator A5032209826 @default.
• W2254879660 creator A5033704013 @default.
• W2254879660 creator A5033800017 @default.
• W2254879660 creator A5040971746 @default.
• W2254879660 creator A5044757881 @default.
• W2254879660 creator A5056851826 @default.
• W2254879660 creator A5059079741 @default.
• W2254879660 creator A5066843240 @default.
• W2254879660 creator A5074845558 @default.
• W2254879660 creator A5075568224 @default.
• W2254879660 creator A5089177966 @default.
• W2254879660 date "2015-10-30" @default.
• W2254879660 modified "2023-09-30" @default.
• W2254879660 title "Resident c-kit+ cells in the heart are not cardiac stem cells" @default.
• W2254879660 cites W1864063551 @default.
• W2254879660 cites W1963756072 @default.
• W2254879660 cites W1966563415 @default.
• W2254879660 cites W1974747739 @default.
• W2254879660 cites W1992644002 @default.
• W2254879660 cites W2010368308 @default.
• W2254879660 cites W2010417854 @default.
• W2254879660 cites W2011549186 @default.
• W2254879660 cites W2015644748 @default.
• W2254879660 cites W2019562841 @default.
• W2254879660 cites W2028036560 @default.
• W2254879660 cites W2029479926 @default.
• W2254879660 cites W2033250271 @default.
• W2254879660 cites W2044953345 @default.
• W2254879660 cites W2045233735 @default.
• W2254879660 cites W2050950457 @default.
• W2254879660 cites W2055323054 @default.
• W2254879660 cites W2066166174 @default.
• W2254879660 cites W2067009965 @default.
• W2254879660 cites W2067335193 @default.
• W2254879660 cites W2070026305 @default.
• W2254879660 cites W2076837609 @default.
• W2254879660 cites W2102248106 @default.
• W2254879660 cites W2104135721 @default.
• W2254879660 cites W2104206289 @default.
• W2254879660 cites W2120911696 @default.
• W2254879660 cites W2126226576 @default.
• W2254879660 cites W2132735690 @default.
• W2254879660 cites W2133460513 @default.
• W2254879660 cites W2136148145 @default.
• W2254879660 cites W2136212502 @default.
• W2254879660 cites W2137382920 @default.
• W2254879660 cites W2138650815 @default.
• W2254879660 cites W2143094150 @default.
• W2254879660 cites W2144304306 @default.
• W2254879660 cites W2148402694 @default.
• W2254879660 cites W2150013759 @default.
• W2254879660 cites W2395939399 @default.
• W2254879660 cites W2519937263 @default.
• W2254879660 cites W2883266913 @default.
• W2254879660 cites W4211016865 @default.
• W2254879660 doi "https://doi.org/10.1038/ncomms9701" @default.
• W2254879660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4846318" @default.
• W2254879660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26515110" @default.
• W2254879660 hasPublicationYear "2015" @default.
• W2254879660 type Work @default.
• W2254879660 sameAs 2254879660 @default.
• W2254879660 citedByCount "258" @default.
• W2254879660 countsByYear W22548796602016 @default.
• W2254879660 countsByYear W22548796602017 @default.
• W2254879660 countsByYear W22548796602018 @default.
• W2254879660 countsByYear W22548796602019 @default.
• W2254879660 countsByYear W22548796602020 @default.
• W2254879660 countsByYear W22548796602021 @default.
• W2254879660 countsByYear W22548796602022 @default.
• W2254879660 countsByYear W22548796602023 @default.
• W2254879660 crossrefType "journal-article" @default.
• W2254879660 hasAuthorship W2254879660A5000696964 @default.
• W2254879660 hasAuthorship W2254879660A5011123465 @default.
• W2254879660 hasAuthorship W2254879660A5018068367 @default.
• W2254879660 hasAuthorship W2254879660A5029133469 @default.
• W2254879660 hasAuthorship W2254879660A5032209826 @default.
• W2254879660 hasAuthorship W2254879660A5033704013 @default.
• W2254879660 hasAuthorship W2254879660A5033800017 @default.
• W2254879660 hasAuthorship W2254879660A5040971746 @default.
• W2254879660 hasAuthorship W2254879660A5044757881 @default.
• W2254879660 hasAuthorship W2254879660A5056851826 @default.
• W2254879660 hasAuthorship W2254879660A5059079741 @default.
• W2254879660 hasAuthorship W2254879660A5066843240 @default.
• W2254879660 hasAuthorship W2254879660A5074845558 @default.
• W2254879660 hasAuthorship W2254879660A5075568224 @default.
• W2254879660 hasAuthorship W2254879660A5089177966 @default.
• W2254879660 hasBestOaLocation W22548796601 @default.
• W2254879660 hasConcept C123012128 @default.
• W2254879660 hasConcept C126322002 @default.
• W2254879660 hasConcept C201750760 @default.
• W2254879660 hasConcept C202751555 @default.
• W2254879660 hasConcept C207200792 @default.
• W2254879660 hasConcept C2778532138 @default.
• W2254879660 hasConcept C2778996579 @default.

• next