FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2254958114> ?p ?o ?g. }

• W2254958114 endingPage "333" @default.
• W2254958114 startingPage "326" @default.
• W2254958114 abstract "Angiogenesis plays a key role in tumor growth, invasion and metastasis of cancer diseases and therefore, the inhibition of angiogenesis can provide an important therapeutic approach in cancer diseases. This study was designed to compare the anti-angiogenic activities of the ethanolic extract of Artemisia sieberi Besser, Asteraceae, and its active substance, artemisinin in both in vitro and in vivo models. To compare cytotoxicity level of ethanolic extract of A. sieberi with artemisinin, different concentrations (1–100 μg/ml) were tested using MTT assay on human umbilical vein endothelial cells. The anti-angiogenic properties of serial concentrations of ethanolic extract of A. sieberi and artemisinin were examined on human umbilical vein endothelial cells using a three-dimensional angiogenesis assay (in vitro model) and in the chick chorioallantoic membrane assay as in vivo model. The effects of ethanolic extract of A. sieberi and artemisinin were also tested on the expression of VEGFR-1, VEGFR-2 and CD34 genes using real-time PCR. Ethanolic extract of A. sieberi and artemisinin significantly (p < 0.001) inhibited the angiogenesis in the human umbilical vein endothelial cells culture whilst the ethanolic extract of A. sieberi showed higher effect in a concentration-dependent fashion (p < 0.001). The chick chorioallantoic membrane angiogenesis was also completely inhibited by ethanolic extract of A. sieberi at concentration of 33 ng/100 μl/egg. The gene expression analysis showed that the ethanolic extract of A. sieberi and artemisinin reduced the transcription of VEGFR-1, VEGFR-2 and CD34 genes in a concentration-dependent manner. This study demonstrated that the ethanolic extract of A. sieberi is strongly able to inhibit the angiogenesis in human umbilical vein endothelial cells and chick chorioallantoic membrane models compared to the artemisinin." @default.
• W2254958114 created "2016-06-24" @default.
• W2254958114 creator A5039925084 @default.
• W2254958114 creator A5056519280 @default.
• W2254958114 creator A5058032590 @default.
• W2254958114 creator A5060689668 @default.
• W2254958114 date "2016-05-01" @default.
• W2254958114 modified "2023-09-27" @default.
• W2254958114 title "Anti-angiogenic effects of ethanolic extract of Artemisia sieberi compared to its active substance, artemisinin" @default.
• W2254958114 cites W158281719 @default.
• W2254958114 cites W1762724222 @default.
• W2254958114 cites W1926681914 @default.
• W2254958114 cites W1957822733 @default.
• W2254958114 cites W1964007315 @default.
• W2254958114 cites W1967537433 @default.
• W2254958114 cites W1967596683 @default.
• W2254958114 cites W1967621966 @default.
• W2254958114 cites W1969259783 @default.
• W2254958114 cites W1975058097 @default.
• W2254958114 cites W1976614321 @default.
• W2254958114 cites W1986125957 @default.
• W2254958114 cites W1989657796 @default.
• W2254958114 cites W1991030067 @default.
• W2254958114 cites W1993494844 @default.
• W2254958114 cites W2000000541 @default.
• W2254958114 cites W2005854408 @default.
• W2254958114 cites W2012063336 @default.
• W2254958114 cites W2013597076 @default.
• W2254958114 cites W2014883125 @default.
• W2254958114 cites W2017640872 @default.
• W2254958114 cites W2018053695 @default.
• W2254958114 cites W2019647403 @default.
• W2254958114 cites W2030426885 @default.
• W2254958114 cites W2032680197 @default.
• W2254958114 cites W2040694163 @default.
• W2254958114 cites W2042706923 @default.
• W2254958114 cites W2043724241 @default.
• W2254958114 cites W2046786765 @default.
• W2254958114 cites W2048380602 @default.
• W2254958114 cites W2053177923 @default.
• W2254958114 cites W2054174404 @default.
• W2254958114 cites W2054618296 @default.
• W2254958114 cites W2060400258 @default.
• W2254958114 cites W2060937624 @default.
• W2254958114 cites W2067965657 @default.
• W2254958114 cites W2074622849 @default.
• W2254958114 cites W2076424556 @default.
• W2254958114 cites W2078500738 @default.
• W2254958114 cites W2079190550 @default.
• W2254958114 cites W2085123647 @default.
• W2254958114 cites W2094633119 @default.
• W2254958114 cites W2098184601 @default.
• W2254958114 cites W2102375186 @default.
• W2254958114 cites W2105168625 @default.
• W2254958114 cites W2105509381 @default.
• W2254958114 cites W2111272254 @default.
• W2254958114 cites W2115706256 @default.
• W2254958114 cites W2123684807 @default.
• W2254958114 cites W2126327738 @default.
• W2254958114 cites W2130860350 @default.
• W2254958114 cites W2131798870 @default.
• W2254958114 cites W2142777712 @default.
• W2254958114 cites W2146835885 @default.
• W2254958114 cites W2150608538 @default.
• W2254958114 cites W2160578379 @default.
• W2254958114 cites W2164418478 @default.
• W2254958114 cites W2166549828 @default.
• W2254958114 cites W2169938865 @default.
• W2254958114 cites W4252851641 @default.
• W2254958114 doi "https://doi.org/10.1016/j.bjp.2015.11.008" @default.
• W2254958114 hasPublicationYear "2016" @default.
• W2254958114 type Work @default.
• W2254958114 sameAs 2254958114 @default.
• W2254958114 citedByCount "17" @default.
• W2254958114 countsByYear W22549581142017 @default.
• W2254958114 countsByYear W22549581142018 @default.
• W2254958114 countsByYear W22549581142019 @default.
• W2254958114 countsByYear W22549581142020 @default.
• W2254958114 countsByYear W22549581142021 @default.
• W2254958114 countsByYear W22549581142022 @default.
• W2254958114 countsByYear W22549581142023 @default.
• W2254958114 crossrefType "journal-article" @default.
• W2254958114 hasAuthorship W2254958114A5039925084 @default.
• W2254958114 hasAuthorship W2254958114A5056519280 @default.
• W2254958114 hasAuthorship W2254958114A5058032590 @default.
• W2254958114 hasAuthorship W2254958114A5060689668 @default.
• W2254958114 hasBestOaLocation W22549581141 @default.
• W2254958114 hasConcept C109316439 @default.
• W2254958114 hasConcept C150903083 @default.
• W2254958114 hasConcept C185592680 @default.
• W2254958114 hasConcept C202751555 @default.
• W2254958114 hasConcept C203014093 @default.
• W2254958114 hasConcept C207001950 @default.
• W2254958114 hasConcept C2776120307 @default.
• W2254958114 hasConcept C2777389444 @default.
• W2254958114 hasConcept C2777411675 @default.
• W2254958114 hasConcept C2778048844 @default.
• W2254958114 hasConcept C2778371730 @default.

• next