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- W2255103973 abstract "Two types of cortical cataract have been produced in larvae of the tiger salamander, Amblystoma tigrinum, by three series of synthetic diets differing in their chief constituent, protein. Eyes were normal in larvae fed raw muscle or liver or artificial diets containing these tissues as chief ingredients. Cataracts rarely visible in an early stage as radiating striae, with swelling followed by extensive shrinking, were produced in 43% of the animals on diets of purified casein and powdered milk and in 51% on diets containing separate muscle proteins. Preparation of each of these materials involved the use of dilute alkali, known to disintegrate cystine. The quantities of this amino acid used as supplements resulted in prevention of the lens disease in larvae fed the casein diet and in two groups of those fed the muscle-protein diets. Riboflavin was not a preventative. Cataracts with an always visible early line of zoning parallel and near to the lens surface appeared in larvae fed high hemoglobin rations. The stage of whitening, which occurred in 37% of the animals, was accompanied by a large fluid content within the lens capsule and subsequent changes were slow. Prevention was not attained with riboflavin nor with a high supplement of cystine alone. A combination of the three amino acids of glutathione reduced the early symptoms of the disease and halted its development, but did not bring about complete prevention." @default.
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- W2255103973 date "1941-10-01" @default.
- W2255103973 modified "2023-10-16" @default.
- W2255103973 title "Dietary Production of Cataracts in Larval Amblystoma Tigrinum" @default.
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- W2255103973 doi "https://doi.org/10.1093/jn/22.4.365" @default.
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