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- W2255121528 abstract "Two critical cell types necessary to produce and maintain hair follicles are fibroblasts, which reside in the dermal papilla (DP) and dermal sheath (DS), and keratinocytes, including hair follicle stem cells (HFSCs) and their progeny. Although keratinocytes are the primary constituents of hair follicle that generate the hair structure, the contribution of dermal fibroblasts to hair follicle neogenesis and regeneration is less well defined. Cells within the DP and DS are specialized fibroblasts of mesenchymal origin, collectively forming a dermal microenvironment encircling the epithelial compartment and exhibiting hair cycle-associated plasticity. DP cells (DPCs) of growing follicles are known to possess hair-inducing ability and interact with keratinocytes to achieve regenerative hair growth; however, attempts to elicit human follicle neogenesis with cultured human DPCs have not been very successful partly because they lose inductivity during passaging [ [1] Kishimoto J. Burgeson R.E. Morgan B.A. Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev. 2000; 14: 1181-1185 PubMed Google Scholar ], suggesting that additional efforts are needed to gain a better understanding of the mesenchyme in intact follicles. In particular, the DS, the second dermal compartment, has received rather little attention." @default.
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- W2255121528 date "2016-05-01" @default.
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- W2255121528 title "Dermal sheath cells contribute to postnatal hair follicle growth and cycling" @default.
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- W2255121528 doi "https://doi.org/10.1016/j.jdermsci.2016.02.002" @default.
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