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- W22551486 abstract "Publisher Summary Antiphospholipid syndrome (APS) is characterized by the development of venous or arterial thromboses, fetal losses, and thrombocytopenia in the presence of antiphospholipid antibodies (aPLs), namely lupus anticoagulant (LA), anticardiolipin antibodies (aCLs), or antibodies directed to various proteins, mainly β 2 -glycoprotein I (β 2 GPI), or all three. This chapter focuses on the treatment of thrombotic and obstetric manifestations of APS. It discusses the therapeutic approach in carriers of aPLs but without previous thrombotic events—that is, patients with systemic lupus erythematosus (SLE) and aPLs, patients with only obstetrical manifestations of APS, and healthy individuals who carry aPLs. It is important to keep in mind that all patients or subjects who present with persistently positive aPLs should control, modify, or discontinue additional vascular risk factors such as hypertension, hypercholesterolemia, or tobacco use. In addition, estrogen-containing oral contraceptives should be avoided in women with aPLs, and prophylaxis with low-molecular-weight heparin should be given in higher risk situations, such as surgery. Following this, the study deals with the management of difficult cases, such as patients for whom their aPL test turns negative or those who do not display formal classification criteria for APS. In this context, there is not sufficient evidence to make recommendations, and in most cases, common sense dictates the therapeutic approach. Finally, it summarizes the evidence-based information about management of catastrophic APS." @default.
- W22551486 created "2016-06-24" @default.
- W22551486 creator A5044648562 @default.
- W22551486 creator A5058436644 @default.
- W22551486 date "2011-01-01" @default.
- W22551486 modified "2023-09-23" @default.
- W22551486 title "Treatment of Antiphospholipid Syndrome" @default.
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