Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255161502> ?p ?o ?g. }
- W2255161502 endingPage "C1056" @default.
- W2255161502 startingPage "C1045" @default.
- W2255161502 abstract "Activated neutrophils display an array of physiological responses, including initiation of the oxidative burst, phagocytosis, and cell migration, that are associated with cellular adhesion. Under conditions that lead to cellular adhesion, we observed rapid tyrosine phosphorylation of an intracellular protein with an approximate relative molecular mass of 92 kDa (p92). Phosphorylation of p92 was inducible when Mac-1 was activated by phorbol 12-myristate 13-acetate, the beta(2)-specific activating antibody CBR LFA-1/2, or interleukin-8 (77 amino acids). In addition, tyrosine phosphorylation of p92 was dependent on engagement of Mac-1 with ligand. Several observations suggest that this event may be an important step in the signaling pathway initiated by Mac-1 binding. p92 phosphorylation was specifically blocked with antibodies to CD11b, the alpha-subunit of Mac-1, and was rapidly reversible on disengagement of the integrin ligand interaction. Integrin-stimulated phosphorylation of p92 created binding sites that were recognized in vitro by the SH2 domains of c-CrkII and Src. Our observations suggest that neutrophil adhesion mediated through the binding of the beta(2)-integrin Mac-1 initiates a signaling cascade that involves the activation of protein tyrosine kinases and leads to the regulation of protein-protein interactions via SH2 domains, a key process shared with growth factor signaling pathways." @default.
- W2255161502 created "2016-06-24" @default.
- W2255161502 creator A5023165455 @default.
- W2255161502 creator A5056029393 @default.
- W2255161502 creator A5071512976 @default.
- W2255161502 date "2001-05-01" @default.
- W2255161502 modified "2023-09-24" @default.
- W2255161502 title "Mac-1-dependent tyrosine phosphorylation during neutrophil adhesion" @default.
- W2255161502 cites W1494810979 @default.
- W2255161502 cites W1537459781 @default.
- W2255161502 cites W1547174896 @default.
- W2255161502 cites W1550039558 @default.
- W2255161502 cites W1550235641 @default.
- W2255161502 cites W1569246394 @default.
- W2255161502 cites W1572472402 @default.
- W2255161502 cites W1578939248 @default.
- W2255161502 cites W1582888773 @default.
- W2255161502 cites W1584454203 @default.
- W2255161502 cites W1586593449 @default.
- W2255161502 cites W1620610430 @default.
- W2255161502 cites W1641682864 @default.
- W2255161502 cites W1855505909 @default.
- W2255161502 cites W190347642 @default.
- W2255161502 cites W1966286149 @default.
- W2255161502 cites W1984718347 @default.
- W2255161502 cites W1998611816 @default.
- W2255161502 cites W1999673185 @default.
- W2255161502 cites W1999824494 @default.
- W2255161502 cites W2002658918 @default.
- W2255161502 cites W2005663928 @default.
- W2255161502 cites W2008323459 @default.
- W2255161502 cites W2009148867 @default.
- W2255161502 cites W2010265636 @default.
- W2255161502 cites W201443300 @default.
- W2255161502 cites W2018324596 @default.
- W2255161502 cites W2020365526 @default.
- W2255161502 cites W2021485845 @default.
- W2255161502 cites W2023313751 @default.
- W2255161502 cites W2029231027 @default.
- W2255161502 cites W2037986253 @default.
- W2255161502 cites W2039965625 @default.
- W2255161502 cites W2044295046 @default.
- W2255161502 cites W2050286820 @default.
- W2255161502 cites W2050556701 @default.
- W2255161502 cites W2051510779 @default.
- W2255161502 cites W2053799953 @default.
- W2255161502 cites W2057784785 @default.
- W2255161502 cites W2058236761 @default.
- W2255161502 cites W2059188737 @default.
- W2255161502 cites W2059289753 @default.
- W2255161502 cites W2061109153 @default.
- W2255161502 cites W2066367871 @default.
- W2255161502 cites W2066371830 @default.
- W2255161502 cites W2069296981 @default.
- W2255161502 cites W2071041511 @default.
- W2255161502 cites W2077634410 @default.
- W2255161502 cites W2090888252 @default.
- W2255161502 cites W2093830420 @default.
- W2255161502 cites W2099675490 @default.
- W2255161502 cites W2100206904 @default.
- W2255161502 cites W2108674983 @default.
- W2255161502 cites W2109594922 @default.
- W2255161502 cites W2112217048 @default.
- W2255161502 cites W2112246383 @default.
- W2255161502 cites W2116067317 @default.
- W2255161502 cites W2122250221 @default.
- W2255161502 cites W2134015622 @default.
- W2255161502 cites W2136969158 @default.
- W2255161502 cites W2138227659 @default.
- W2255161502 cites W2141708077 @default.
- W2255161502 cites W2143169091 @default.
- W2255161502 cites W2157952919 @default.
- W2255161502 cites W2163361020 @default.
- W2255161502 cites W2164241215 @default.
- W2255161502 cites W2167862066 @default.
- W2255161502 cites W2177562606 @default.
- W2255161502 cites W2236313857 @default.
- W2255161502 cites W2336939324 @default.
- W2255161502 cites W2342443089 @default.
- W2255161502 cites W2345689701 @default.
- W2255161502 cites W2407126232 @default.
- W2255161502 cites W2472449491 @default.
- W2255161502 cites W40933246 @default.
- W2255161502 cites W90048484 @default.
- W2255161502 doi "https://doi.org/10.1152/ajpcell.2001.280.5.c1045" @default.
- W2255161502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11287316" @default.
- W2255161502 hasPublicationYear "2001" @default.
- W2255161502 type Work @default.
- W2255161502 sameAs 2255161502 @default.
- W2255161502 citedByCount "16" @default.
- W2255161502 countsByYear W22551615022015 @default.
- W2255161502 countsByYear W22551615022016 @default.
- W2255161502 countsByYear W22551615022023 @default.
- W2255161502 crossrefType "journal-article" @default.
- W2255161502 hasAuthorship W2255161502A5023165455 @default.
- W2255161502 hasAuthorship W2255161502A5056029393 @default.
- W2255161502 hasAuthorship W2255161502A5071512976 @default.
- W2255161502 hasConcept C104551158 @default.