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- W2255201609 abstract "Significance Fibroblast growth factor 1 (FGF1) is critical for adipose tissue remodeling under conditions of dietary stress. Pharmacological treatment with recombinant FGF1 (rFGF1) has potent glucose-lowering, insulin-sensitizing, and antisteatotic effects in hyperglycemic mouse models, but the mechanism is largely unknown. Here we characterize the effects of rFGF1 on nonalcoholic liver disease in two etiologically different mouse models. Strong antisteatotic effects of rFGF1 were observed in ob/ob mice but not in choline-deficient mice, suggesting that rFGF1 exerts its antisteatotic effect via processes specifically impaired in choline-deficient mice, such as lipid oxidation and lipoprotein secretion. In contrast, hepatic inflammation and alanine aminotransferase levels were reduced in both models, indicating that these effects are independent of the antisteatotic properties of rFGF1." @default.
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- W2255201609 date "2016-02-08" @default.
- W2255201609 modified "2023-10-10" @default.
- W2255201609 title "Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease" @default.
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- W2255201609 doi "https://doi.org/10.1073/pnas.1525093113" @default.
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