Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255204992> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2255204992 endingPage "168" @default.
- W2255204992 startingPage "161" @default.
- W2255204992 abstract "Introduction and Aims: Omeprazole is a gastric parietal cells proton pump inhibitor that is also active against H. pylori in vitro. This study was designed to examine the neutralization of H. pylori cytotoxicity on Vero cells by omeprazole micronized in strains isolated from gastritis, ulcer, cancer and Barrett's ulcer, to determine whether omeprazole can inhibit vacuolation of the Vero cells induced by cytotoxin of H. pylori or by urease. The effect of omeprazole on motility of H. pylori was assessed using concentrations lower than MIC. Materials and Methods: The antimicrobial activity of omeprazole micronized was studied by determining the MICs for 15 H. pylori strains. Water extract of the bacteria (concentrated culture supernatant) and different concentrations of omeprazole were added to Vero cells in culture. Also extracted urease from H. pylori strains with urea (10 mM) and omeprazole were added to Vero cells in culture. The inhibitory effect of omeprazole on motility of H. pylori was tested in semi-solid medium. Results: MIC of omeprazole micronized was 20 µ | g/ml. Omeprazole could inhibit induced vacuolation by the water extract of H. pylori strains in Vero cells. It could also inhibit vacuolation induced by urease. Inhibition of vacuolation strains was assessed microscopically and by the neutral red method. It was also found that omeprazole inhibits the motility of H. pylori strains at concentrations lower than MIC. Conclusions: The results of this study suggest that omeprazole micronized could neutralize the vacuolation effect of H. pylori cytotoxin on Vero cells probably by targeting v-type ATPase. The bacterial motility was also inhibited by low concentrations of omeprazole. The results of this study considers omeprazole micronized as an effective drug which targets important virulence factors of H. pylori including vacuolating cytotoxin, urease, and motility." @default.
- W2255204992 created "2016-06-24" @default.
- W2255204992 creator A5002729038 @default.
- W2255204992 creator A5014214187 @default.
- W2255204992 creator A5018868905 @default.
- W2255204992 creator A5029738861 @default.
- W2255204992 creator A5049539275 @default.
- W2255204992 creator A5075589424 @default.
- W2255204992 date "2004-01-01" @default.
- W2255204992 modified "2023-09-23" @default.
- W2255204992 title "Neutralization of Helicobacter Pylori Cytotoxicity on Vero Cells by Omeprazole" @default.
- W2255204992 hasPublicationYear "2004" @default.
- W2255204992 type Work @default.
- W2255204992 sameAs 2255204992 @default.
- W2255204992 citedByCount "0" @default.
- W2255204992 crossrefType "journal-article" @default.
- W2255204992 hasAuthorship W2255204992A5002729038 @default.
- W2255204992 hasAuthorship W2255204992A5014214187 @default.
- W2255204992 hasAuthorship W2255204992A5018868905 @default.
- W2255204992 hasAuthorship W2255204992A5029738861 @default.
- W2255204992 hasAuthorship W2255204992A5049539275 @default.
- W2255204992 hasAuthorship W2255204992A5075589424 @default.
- W2255204992 hasConcept C109316439 @default.
- W2255204992 hasConcept C181199279 @default.
- W2255204992 hasConcept C185592680 @default.
- W2255204992 hasConcept C202751555 @default.
- W2255204992 hasConcept C2776409635 @default.
- W2255204992 hasConcept C2777498785 @default.
- W2255204992 hasConcept C2779521917 @default.
- W2255204992 hasConcept C54355233 @default.
- W2255204992 hasConcept C55493867 @default.
- W2255204992 hasConcept C86803240 @default.
- W2255204992 hasConcept C89138240 @default.
- W2255204992 hasConcept C89423630 @default.
- W2255204992 hasConcept C98274493 @default.
- W2255204992 hasConceptScore W2255204992C109316439 @default.
- W2255204992 hasConceptScore W2255204992C181199279 @default.
- W2255204992 hasConceptScore W2255204992C185592680 @default.
- W2255204992 hasConceptScore W2255204992C202751555 @default.
- W2255204992 hasConceptScore W2255204992C2776409635 @default.
- W2255204992 hasConceptScore W2255204992C2777498785 @default.
- W2255204992 hasConceptScore W2255204992C2779521917 @default.
- W2255204992 hasConceptScore W2255204992C54355233 @default.
- W2255204992 hasConceptScore W2255204992C55493867 @default.
- W2255204992 hasConceptScore W2255204992C86803240 @default.
- W2255204992 hasConceptScore W2255204992C89138240 @default.
- W2255204992 hasConceptScore W2255204992C89423630 @default.
- W2255204992 hasConceptScore W2255204992C98274493 @default.
- W2255204992 hasIssue "3" @default.
- W2255204992 hasLocation W22552049921 @default.
- W2255204992 hasOpenAccess W2255204992 @default.
- W2255204992 hasPrimaryLocation W22552049921 @default.
- W2255204992 hasRelatedWork W1965233822 @default.
- W2255204992 hasRelatedWork W1968061852 @default.
- W2255204992 hasRelatedWork W1999768369 @default.
- W2255204992 hasRelatedWork W2001130388 @default.
- W2255204992 hasRelatedWork W2005251175 @default.
- W2255204992 hasRelatedWork W2011892189 @default.
- W2255204992 hasRelatedWork W2021789367 @default.
- W2255204992 hasRelatedWork W2030457282 @default.
- W2255204992 hasRelatedWork W2045468798 @default.
- W2255204992 hasRelatedWork W2058602545 @default.
- W2255204992 hasRelatedWork W2108971913 @default.
- W2255204992 hasRelatedWork W2123117050 @default.
- W2255204992 hasRelatedWork W2144312876 @default.
- W2255204992 hasRelatedWork W2320390152 @default.
- W2255204992 hasRelatedWork W2332102327 @default.
- W2255204992 hasRelatedWork W2417972854 @default.
- W2255204992 hasRelatedWork W2811490513 @default.
- W2255204992 hasRelatedWork W3097119975 @default.
- W2255204992 hasRelatedWork W2486391267 @default.
- W2255204992 hasRelatedWork W2512480995 @default.
- W2255204992 hasVolume "9" @default.
- W2255204992 isParatext "false" @default.
- W2255204992 isRetracted "false" @default.
- W2255204992 magId "2255204992" @default.
- W2255204992 workType "article" @default.