Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255205412> ?p ?o ?g. }
- W2255205412 endingPage "551" @default.
- W2255205412 startingPage "540" @default.
- W2255205412 abstract "Modern medical oncology has introduced various anti-cancer drugs since the World War I and II. Unlike for the solid tumors, hematological malignancies had been documented some limitations for curing it with chemotherapeutic agents only. In 1960, Dr. Nowell and Dr. Hungerford had discovered elongated chromosome (Philadelphia chromosome) which has documented as a product of translocation between 9th and 22nd chromosome in the patients with chronic myeloid leukemia. In 1970s, immunochemistry technique using monoclonal antibody has spread world widely and from 1990s, flow cytometry method has been available. In appreciation of these evolutions in basic science, the treatment strategy ofhematological malignancies have changed from the chemotherapeutic agents to targeted agents. Among the targeted agents, some drugs are newly developed and others are recreated as anti-cancer drugs after long-time of discard because of their toxicities or teratogenic effects. Nowadays, we are in the middle of flood of targeted agents, for example, tyrosinekinase inhibitors, epidermal growth factor receptor blockers, farnesyl transferase inhibitors, histone deacetylase inhibitors, and etc. In 21st century, the optimal treatment of hematological malignancies should follow a tailor-made strategy according to the patient and disease itself. In the present article, some representative agents will be introduced in accordance with target diseases. (Korean J Med 78:540-551, 2010)" @default.
- W2255205412 created "2016-06-24" @default.
- W2255205412 creator A5028137817 @default.
- W2255205412 creator A5056963227 @default.
- W2255205412 date "2010-01-01" @default.
- W2255205412 modified "2023-09-23" @default.
- W2255205412 title "New drugs in hematological disorders" @default.
- W2255205412 cites W1497973518 @default.
- W2255205412 cites W1533898383 @default.
- W2255205412 cites W1573890015 @default.
- W2255205412 cites W187238933 @default.
- W2255205412 cites W1891395840 @default.
- W2255205412 cites W1983852790 @default.
- W2255205412 cites W1986635169 @default.
- W2255205412 cites W1992935261 @default.
- W2255205412 cites W2006058034 @default.
- W2255205412 cites W2014316424 @default.
- W2255205412 cites W2014654561 @default.
- W2255205412 cites W2016973656 @default.
- W2255205412 cites W2021333892 @default.
- W2255205412 cites W2028959752 @default.
- W2255205412 cites W2029595590 @default.
- W2255205412 cites W2029854218 @default.
- W2255205412 cites W2046269728 @default.
- W2255205412 cites W2050642909 @default.
- W2255205412 cites W2053631011 @default.
- W2255205412 cites W2058015212 @default.
- W2255205412 cites W2060376769 @default.
- W2255205412 cites W2078761761 @default.
- W2255205412 cites W2080100636 @default.
- W2255205412 cites W2081279521 @default.
- W2255205412 cites W2092509861 @default.
- W2255205412 cites W2094591634 @default.
- W2255205412 cites W2096638244 @default.
- W2255205412 cites W2099145932 @default.
- W2255205412 cites W2102776788 @default.
- W2255205412 cites W2106584820 @default.
- W2255205412 cites W2107268345 @default.
- W2255205412 cites W2108472756 @default.
- W2255205412 cites W2114492363 @default.
- W2255205412 cites W2120204058 @default.
- W2255205412 cites W2128177827 @default.
- W2255205412 cites W2136735139 @default.
- W2255205412 cites W2140291353 @default.
- W2255205412 cites W2142969636 @default.
- W2255205412 cites W2153558008 @default.
- W2255205412 cites W2160305510 @default.
- W2255205412 cites W2160881482 @default.
- W2255205412 cites W2267583049 @default.
- W2255205412 cites W2275311108 @default.
- W2255205412 cites W2281742031 @default.
- W2255205412 cites W2515141082 @default.
- W2255205412 cites W2550532673 @default.
- W2255205412 cites W2560777339 @default.
- W2255205412 cites W2579504722 @default.
- W2255205412 cites W2581220283 @default.
- W2255205412 cites W2591760772 @default.
- W2255205412 cites W2593925885 @default.
- W2255205412 cites W27058374 @default.
- W2255205412 hasPublicationYear "2010" @default.
- W2255205412 type Work @default.
- W2255205412 sameAs 2255205412 @default.
- W2255205412 citedByCount "0" @default.
- W2255205412 crossrefType "journal-article" @default.
- W2255205412 hasAuthorship W2255205412A5028137817 @default.
- W2255205412 hasAuthorship W2255205412A5056963227 @default.
- W2255205412 hasConcept C121608353 @default.
- W2255205412 hasConcept C126322002 @default.
- W2255205412 hasConcept C203014093 @default.
- W2255205412 hasConcept C502942594 @default.
- W2255205412 hasConcept C71924100 @default.
- W2255205412 hasConcept C98274493 @default.
- W2255205412 hasConceptScore W2255205412C121608353 @default.
- W2255205412 hasConceptScore W2255205412C126322002 @default.
- W2255205412 hasConceptScore W2255205412C203014093 @default.
- W2255205412 hasConceptScore W2255205412C502942594 @default.
- W2255205412 hasConceptScore W2255205412C71924100 @default.
- W2255205412 hasConceptScore W2255205412C98274493 @default.
- W2255205412 hasIssue "5" @default.
- W2255205412 hasLocation W22552054121 @default.
- W2255205412 hasOpenAccess W2255205412 @default.
- W2255205412 hasPrimaryLocation W22552054121 @default.
- W2255205412 hasRelatedWork W109492528 @default.
- W2255205412 hasRelatedWork W109541353 @default.
- W2255205412 hasRelatedWork W1589795697 @default.
- W2255205412 hasRelatedWork W1613742590 @default.
- W2255205412 hasRelatedWork W1834961169 @default.
- W2255205412 hasRelatedWork W1987354263 @default.
- W2255205412 hasRelatedWork W2049527716 @default.
- W2255205412 hasRelatedWork W2134061119 @default.
- W2255205412 hasRelatedWork W2234071502 @default.
- W2255205412 hasRelatedWork W2397139343 @default.
- W2255205412 hasRelatedWork W2409522741 @default.
- W2255205412 hasRelatedWork W2511118013 @default.
- W2255205412 hasRelatedWork W2591376661 @default.
- W2255205412 hasRelatedWork W2761079385 @default.
- W2255205412 hasRelatedWork W2785810587 @default.
- W2255205412 hasRelatedWork W2788789829 @default.