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• W2255246323 abstract "Here we report the solid phase synthesis and characterization (LC-ESIMS, CD) of a cationic nucleobase-containing α-peptide, composed of both l-arginine residues and l-lysine-based nucleoamino acids sequentially present in the structure. The binding properties of this novel basic nucleopeptide towards nucleic acids were investigated by CD spectroscopy which revealed the ability of the thymine-containing oligomer to bind both adenine-containing DNA (dA12) and RNA (poly rA) molecules inducing high conformational variations in the nucleic acid structures. Moreover, the artificial oligonucleotide inhibited the enzymatic activity of HIV reverse transcriptase, opening the door to the exploitation of novel antiviral strategies inspired to this molecular tool." @default.
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• W2255246323 date "2016-01-01" @default.
• W2255246323 modified "2023-10-14" @default.
• W2255246323 title "Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide" @default.
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• W2255246323 doi "https://doi.org/10.1039/c5ra25809j" @default.
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