FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255260047> ?p ?o ?g. }

• W2255260047 endingPage "2" @default.
• W2255260047 startingPage "2" @default.
• W2255260047 abstract "Recognition of tumor cells by cytolytic T lymphocytes depends on cell surface MHC class I expression. As a mechanism to evade T cell recognition, many malignant cancer cells, including those of prostate cancer, down-regulate MHC class I. For the majority of human cancers, the molecular mechanism of MHC class I down regulation is unclear, although it is well established that MHC class I down-regulation is often associated with the down-regulation of multiple genes devoted to antigen presentation. Since the promyelocytic leukemia (PML) proto-oncogene controls multiple antigen-presentation genes in some murine cancer cells, we analyzed the expression of proto-oncogene PML and MHC class I in high-grade prostate cancer. We found that 30 of 37 (81%) prostate adenocarcinoma cases with a Gleason grade of 7-8 had more than 50% down-regulation of HLA class I expression. Among these, 22 cases (73.3%) had no detectable PML protein, while 4 cases (13.3%) showed partial PML down-regulation. In contrast, all 7 cases of prostate cancer with high expression of cell surface HLA class I had high levels of PML expression. Concordant down-regulation of HLA and PML was observed in different histological patterns of prostate adenocarcinoma. These results suggest that in high-grade prostate cancer, malfunction of proto-oncogene PML is a major factor in the down-regulation of cell surface HLA class I molecules, the target molecules essential for the direct recognition of cancer cells by cytolytic T lymphocytes." @default.
• W2255260047 created "2016-06-24" @default.
• W2255260047 creator A5011447518 @default.
• W2255260047 creator A5014994783 @default.
• W2255260047 creator A5019693604 @default.
• W2255260047 creator A5023037940 @default.
• W2255260047 creator A5023363049 @default.
• W2255260047 creator A5027899074 @default.
• W2255260047 creator A5040907593 @default.
• W2255260047 creator A5056309387 @default.
• W2255260047 creator A5070457128 @default.
• W2255260047 creator A5083827557 @default.
• W2255260047 date "2003-02-14" @default.
• W2255260047 modified "2023-10-01" @default.
• W2255260047 title "Concordant down-regulation of proto-oncogene PML and major histocompatibility antigen HLA class I expression in high-grade prostate cancer." @default.
• W2255260047 cites W126620920 @default.
• W2255260047 cites W1444462873 @default.
• W2255260047 cites W1495399046 @default.
• W2255260047 cites W1665146230 @default.
• W2255260047 cites W1819529703 @default.
• W2255260047 cites W1953976277 @default.
• W2255260047 cites W19706157 @default.
• W2255260047 cites W1975647987 @default.
• W2255260047 cites W1978416272 @default.
• W2255260047 cites W1980221011 @default.
• W2255260047 cites W1984832220 @default.
• W2255260047 cites W2017670466 @default.
• W2255260047 cites W2018227907 @default.
• W2255260047 cites W2019653601 @default.
• W2255260047 cites W2021844024 @default.
• W2255260047 cites W2024050392 @default.
• W2255260047 cites W2029993034 @default.
• W2255260047 cites W2046451544 @default.
• W2255260047 cites W2055034075 @default.
• W2255260047 cites W2073520179 @default.
• W2255260047 cites W2076537666 @default.
• W2255260047 cites W2077301617 @default.
• W2255260047 cites W2083988731 @default.
• W2255260047 cites W2084416493 @default.
• W2255260047 cites W2088342139 @default.
• W2255260047 cites W2101255595 @default.
• W2255260047 cites W2103973613 @default.
• W2255260047 cites W2109721791 @default.
• W2255260047 cites W2145679164 @default.
• W2255260047 cites W2147976450 @default.
• W2255260047 cites W2166192944 @default.
• W2255260047 cites W2171935047 @default.
• W2255260047 cites W2349905826 @default.
• W2255260047 cites W2418666954 @default.
• W2255260047 cites W3021254998 @default.
• W2255260047 cites W308634776 @default.
• W2255260047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12747744" @default.
• W2255260047 hasPublicationYear "2003" @default.
• W2255260047 type Work @default.
• W2255260047 sameAs 2255260047 @default.
• W2255260047 citedByCount "15" @default.
• W2255260047 countsByYear W22552600472014 @default.
• W2255260047 countsByYear W22552600472016 @default.
• W2255260047 countsByYear W22552600472021 @default.
• W2255260047 countsByYear W22552600472022 @default.
• W2255260047 countsByYear W22552600472023 @default.
• W2255260047 crossrefType "journal-article" @default.
• W2255260047 hasAuthorship W2255260047A5011447518 @default.
• W2255260047 hasAuthorship W2255260047A5014994783 @default.
• W2255260047 hasAuthorship W2255260047A5019693604 @default.
• W2255260047 hasAuthorship W2255260047A5023037940 @default.
• W2255260047 hasAuthorship W2255260047A5023363049 @default.
• W2255260047 hasAuthorship W2255260047A5027899074 @default.
• W2255260047 hasAuthorship W2255260047A5040907593 @default.
• W2255260047 hasAuthorship W2255260047A5056309387 @default.
• W2255260047 hasAuthorship W2255260047A5070457128 @default.
• W2255260047 hasAuthorship W2255260047A5083827557 @default.
• W2255260047 hasConcept C111441629 @default.
• W2255260047 hasConcept C121608353 @default.
• W2255260047 hasConcept C147483822 @default.
• W2255260047 hasConcept C170627219 @default.
• W2255260047 hasConcept C188280979 @default.
• W2255260047 hasConcept C203014093 @default.
• W2255260047 hasConcept C207936829 @default.
• W2255260047 hasConcept C2775890610 @default.
• W2255260047 hasConcept C2776090121 @default.
• W2255260047 hasConcept C2776601000 @default.
• W2255260047 hasConcept C2778814158 @default.
• W2255260047 hasConcept C2780192828 @default.
• W2255260047 hasConcept C2781018059 @default.
• W2255260047 hasConcept C2781121885 @default.
• W2255260047 hasConcept C29537977 @default.
• W2255260047 hasConcept C502942594 @default.
• W2255260047 hasConcept C54355233 @default.
• W2255260047 hasConcept C81885089 @default.
• W2255260047 hasConcept C83464605 @default.
• W2255260047 hasConcept C86803240 @default.
• W2255260047 hasConcept C8891405 @default.
• W2255260047 hasConceptScore W2255260047C111441629 @default.
• W2255260047 hasConceptScore W2255260047C121608353 @default.
• W2255260047 hasConceptScore W2255260047C147483822 @default.
• W2255260047 hasConceptScore W2255260047C170627219 @default.
• W2255260047 hasConceptScore W2255260047C188280979 @default.

• next