Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255337597> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2255337597 endingPage "R748" @default.
- W2255337597 startingPage "R739" @default.
- W2255337597 abstract "Angiotensin II (ANG II; 10 or 30 ng/min iv) was infused for 7-10 days in unilaterally adrenalectomized and nephrectomized Sprague-Dawley rats drinking 1% NaCl. The acute pressure-natriuresis relationship was studied under Inactin anesthesia in volume-expanded rats with fixed neurohumoral influences on the remaining kidney. Renal interstitial hydrostatic pressure (RIHP) was measured using a catheter implanted into the renal cortex. Arterial blood pressure before laparotomy was 149 +/- 3 (SE) mmHg (n = 6) and 152 +/- 6 mmHg (n = 16) for ANG II-infused rats (10 and 30 ng/min, respectively) and 123 +/- 5 mmHg (n = 6) and 123 +/- 7 mmHg (n = 16) for the respective control rats. Compared with values in control rats, ANG II-infused rats had significantly (P < 0.05) lower urine flow and absolute and fractional sodium excretion at renal artery pressures of 115-150 mmHg. There were no significant differences between RIHP measured in control and ANG II-hypertensive rats. The shift in the pressure-diuresis, pressure-natriuresis, and pressure-fractional sodium excretion relationships was similar with both doses of ANG II and was reversed by the acute administration of losartan (10 mg/kg iv). In all groups of rats, renal blood flow was autoregulated, whereas glomerular filtration rate was not autoregulated in ANG II-infused rats and was significantly lower than that in control rats at the lower level of renal artery pressure. The data indicate that rats with ANG II-induced hypertension have a rightward shift of the pressure-natriuresis curve caused primarily by a decrease in fractional excretion of sodium. The lack of effect of chronic ANG II infusion on filtration fraction and RIHP suggests that the increased tubular reabsorption was due to a direct action of ANG II on renal tubules. The reversal of these effects by losartan suggests that the shift in the pressure-natriuresis curve in ANG II-induced hypertension is mediated by the AT1-receptor subtype." @default.
- W2255337597 created "2016-06-24" @default.
- W2255337597 creator A5014627822 @default.
- W2255337597 creator A5076775541 @default.
- W2255337597 date "1994-03-01" @default.
- W2255337597 modified "2023-10-11" @default.
- W2255337597 title "Altered pressure natriuresis in chronic angiotensin II hypertension in rats" @default.
- W2255337597 doi "https://doi.org/10.1152/ajpregu.1994.266.3.r739" @default.
- W2255337597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8160866" @default.
- W2255337597 hasPublicationYear "1994" @default.
- W2255337597 type Work @default.
- W2255337597 sameAs 2255337597 @default.
- W2255337597 citedByCount "23" @default.
- W2255337597 countsByYear W22553375972012 @default.
- W2255337597 countsByYear W22553375972013 @default.
- W2255337597 countsByYear W22553375972014 @default.
- W2255337597 countsByYear W22553375972015 @default.
- W2255337597 countsByYear W22553375972016 @default.
- W2255337597 countsByYear W22553375972019 @default.
- W2255337597 countsByYear W22553375972022 @default.
- W2255337597 crossrefType "journal-article" @default.
- W2255337597 hasAuthorship W2255337597A5014627822 @default.
- W2255337597 hasAuthorship W2255337597A5076775541 @default.
- W2255337597 hasConcept C126322002 @default.
- W2255337597 hasConcept C134018914 @default.
- W2255337597 hasConcept C142225936 @default.
- W2255337597 hasConcept C159641895 @default.
- W2255337597 hasConcept C174459258 @default.
- W2255337597 hasConcept C185592680 @default.
- W2255337597 hasConcept C198710026 @default.
- W2255337597 hasConcept C2779547328 @default.
- W2255337597 hasConcept C2780288358 @default.
- W2255337597 hasConcept C2780343553 @default.
- W2255337597 hasConcept C2908929049 @default.
- W2255337597 hasConcept C71924100 @default.
- W2255337597 hasConcept C84393581 @default.
- W2255337597 hasConceptScore W2255337597C126322002 @default.
- W2255337597 hasConceptScore W2255337597C134018914 @default.
- W2255337597 hasConceptScore W2255337597C142225936 @default.
- W2255337597 hasConceptScore W2255337597C159641895 @default.
- W2255337597 hasConceptScore W2255337597C174459258 @default.
- W2255337597 hasConceptScore W2255337597C185592680 @default.
- W2255337597 hasConceptScore W2255337597C198710026 @default.
- W2255337597 hasConceptScore W2255337597C2779547328 @default.
- W2255337597 hasConceptScore W2255337597C2780288358 @default.
- W2255337597 hasConceptScore W2255337597C2780343553 @default.
- W2255337597 hasConceptScore W2255337597C2908929049 @default.
- W2255337597 hasConceptScore W2255337597C71924100 @default.
- W2255337597 hasConceptScore W2255337597C84393581 @default.
- W2255337597 hasIssue "3" @default.
- W2255337597 hasLocation W22553375971 @default.
- W2255337597 hasLocation W22553375972 @default.
- W2255337597 hasOpenAccess W2255337597 @default.
- W2255337597 hasPrimaryLocation W22553375971 @default.
- W2255337597 hasRelatedWork W1648623379 @default.
- W2255337597 hasRelatedWork W1966119954 @default.
- W2255337597 hasRelatedWork W1981626491 @default.
- W2255337597 hasRelatedWork W1993617885 @default.
- W2255337597 hasRelatedWork W2010218270 @default.
- W2255337597 hasRelatedWork W2163731487 @default.
- W2255337597 hasRelatedWork W2283093578 @default.
- W2255337597 hasRelatedWork W2305750766 @default.
- W2255337597 hasRelatedWork W2407791909 @default.
- W2255337597 hasRelatedWork W2724419664 @default.
- W2255337597 hasVolume "266" @default.
- W2255337597 isParatext "false" @default.
- W2255337597 isRetracted "false" @default.
- W2255337597 magId "2255337597" @default.
- W2255337597 workType "article" @default.