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- W2255377377 abstract "Abstract Ovarian cancer is an immune reactive tumor with a complex suppressive network that blunts immune eradication. One putative pathway of evasion may be recruitment of CD4 regulatory T cells (Treg) into the tumor microenvironment. This study investigated the association of tumor infiltrating Tregs in ovarian cancer patients with poor survival. Methods: Immunofluorescence of intraepithelial CD4+CD25+FOXP3+ Tregs, CD3+ and CD8+ cells was performed in tumors of 52 ovarian cancer patients. Average and maximum count of cells were associated with survival via Cox regression models and summarized with hazard ratios (HR) and 95% confidence intervals (CIs). Results: The maximum counts of Tregs in these patients suggests an association between higher number of Tregs and poor clinical outcome (HR=1.48, CI=0.97, 2.28), although not statistically significant (p=0.07). Moreover, presence of high CD8/Treg ratio (HR=0.7, CI=0.53, 0.91; p=0.008) as well as high CD8/CD4 ratio (HR=0.76, CI=0.57, 1.0; p=0.05) appear to be associated with good outcome. The CD3 lymphocyte count was not associated with survival (HR=0.9, CI=0.66, 1.24; p=0.52). Conclusion: Although the present pilot study was conducted with a limited number of patients, our data suggests that higher numbers of infiltrating Tregs might be associated with poor survival and low CD8/Treg ratio may be correlated with improved survival in patients with epithelial ovarian carcinoma. We plan to confirm these results in a larger set of patients." @default.
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- W2255377377 date "2012-05-01" @default.
- W2255377377 modified "2023-09-25" @default.
- W2255377377 title "CD4+CD25+FOXP3+ regulatory T cells and association with survival in epithelial ovarian cancer (74.9)" @default.
- W2255377377 doi "https://doi.org/10.4049/jimmunol.188.supp.74.9" @default.
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