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- W2255437610 abstract "4993 Occupational exposure to asbestos is associated with the development of asbestosis, malignant mesothelioma, and lung cancer. Asbestos fibers have been shown to act as genotoxic and cytotoxic agents that can produce both DNA and chromosomal damage. Both direct and indirect interaction of asbestos fibers and target cells are assumed to lead to DNA damage despite the exact mechanisms are yet to be discovered. We performed DNA copy number and gene expression microarrays on lung tumor samples from 14 highly asbestos-exposed and from 14 non-exposed patients with the aim to identify potential asbestos-associated aberrations. To identify chromosomal regions with DNA copy number and expressional differences between the tumors of exposed and non-exposed patients, the gene expression data was combined with CGH microarray data and analyzed at group level. The identification of exposure-related areas was performed by using overlapping 0.5-1 Mbp segments, and each segment was tested for differences in copy numbers and gene expression between the exposed and non-exposed groups. The exposure-associated regions were identified by means of hypothesis testing. By combining the gene expression data with the DNA copy number data, we identified six chromosomal regions showing association to asbestos-exposure on both DNA and mRNA level. One of these regions, namely 19p13.3.-13.1, was further characterized by microsatellite analysis in 62 patients for allelic imbalance differences between tumors of non-exposed and exposed patients. Our results suggest that the loss of the 19p-region is significantly associated with asbestos-exposure. Furthermore, in tumors of asbestos-exposed patients, AI in 19p seems to appear regardless of the histological tumor type whereas in tumors of non-exposed patients AI is more restricted to certain tumor types." @default.
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- W2255437610 date "2007-05-01" @default.
- W2255437610 modified "2023-09-23" @default.
- W2255437610 title "Microarray screening and microsatellite analysis suggest the significance of allelic imbalance of 19p-region in asbestos-associated lung cancer" @default.
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