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- W2255447737 abstract "The aim of this study was to investigate the physicochemical properties of Nateglinide in inclusion complex. The phase solubility behavior of Nateglinide in presence of various concentrations of β-CD in pH 7.4 buffers was obtained at 37°C. The solubility of Nateglinide increased with increasing the concentration of β-CD. The inclusion complex of Nateglinide with β-CD were prepared at in various ratios (C1-1:1 Nateglinide: β-CD, C2-1:2 Nateglinide: β-CD, C3 1:3 Nateglinide: β-CD) using Kneading method. Prepared inclusion complexes were evaluated by FT-IR, LC-MS, DSC, NMR and SEM. The FT-IR spectroscopic studies showed the stability of Nateglinide and absence of welldefined Nateglinide-β-CD interaction. Among all prepared inclusion complexes, C3 showed the best release pattern." @default.
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- W2255447737 date "2011-07-28" @default.
- W2255447737 modified "2023-09-22" @default.
- W2255447737 title "Enhancement of Nateglinide Solubility and Dissolution Rate" @default.
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