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- W2255480790 abstract "To solve the problem of the significance of competing interrelationships between divalent cations and Be in the mechanism of the toxic action of Be, its influence on the ability of pulverized rat liver tissue to oxidize ketoglutaric (I), succinic (II), and beta-hydroxybutyric (III) acids was studied. A pH 7.4 bicarbonate Ringer solution was used as the medium. Be was added in amounts of 0.01M. Tissue respiration was determined in a Warburg apparatus in an atmosphere of O/sub 2/ for one hour at 37 deg C. The addition of Be to a tissue pulp in the absence of the indicnted substrates in the medium or in the presence of H and III in it reduced the O/sub 2/ consumption to approximately the same degree, i.e., Be inhibited tissue respiration and did not influence the oxidation of II and III. At the same time, Be sharply suppressed the oxidation of I (malonic acid was added to the incubation medium to suppress the succinic dehydrogenase activity). Since the oxidation of II and III is unchanged in the presence of Be, while the oxidation of I is restrained, the hypothesis is advanced that the site of application of the action of Be is themore » dehydrogenase catalyzing the transfer of H/ sub 2/ from I to DPN, or an enzyme activated by Mg. (OTS)« less" @default.
- W2255480790 created "2016-06-24" @default.
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- W2255480790 date "1962-01-01" @default.
- W2255480790 modified "2023-09-26" @default.
- W2255480790 title "INFLUENCE OF BERYLLIUM ON TISSUE RESPIRATION" @default.
- W2255480790 hasPublicationYear "1962" @default.
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