Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255520919> ?p ?o ?g. }
- W2255520919 endingPage "858" @default.
- W2255520919 startingPage "843" @default.
- W2255520919 abstract "It has become increasingly clear that dietary habits may affect the risk/progression of chronic diseases with a pathogenic inflammatory component, such as colorectal cancer. Considerable attention has been directed toward the ability of nutritional agents to target key molecular pathways involved in these inflammatory-related diseases.ω-3 Polyunsaturated fatty acids (PUFA) and their oxidative metabolites have attracted considerable interest as possible anti-inflammatory and anti-cancer agents, especially in areas such as the large bowel, where the influence of orally introduced substances is high and tumors show deranged PUFA patterns. On this basis, we have analyzed pre-clinical findings that have recently revealed new insight into the molecular pathways targeted by ω-3 PUFA.The findings analyzed herein demonstrate that ω-3 PUFA may exert beneficial effects by targeting the epigenetic regulation of gene expression and altering M2 macrophage polarization during the inflammatory response. These mechanisms need to be better explored in the large bowel, and further studies could better clarify their role and the potential of dietary interventions with ω-3 PUFA in the large bowel. The epigenomic mechanism is discussed in view of the potential of ω-3 PUFA to enhance the efficacy of other agents used in the therapy of colorectal cancer." @default.
- W2255520919 created "2016-06-24" @default.
- W2255520919 creator A5000367695 @default.
- W2255520919 creator A5032710097 @default.
- W2255520919 creator A5083025770 @default.
- W2255520919 creator A5083644767 @default.
- W2255520919 date "2016-02-07" @default.
- W2255520919 modified "2023-09-30" @default.
- W2255520919 title "Epigenetic regulation of gene expression and M2 macrophage polarization as new potential omega-3 polyunsaturated fatty acid targets in colon inflammation and cancer" @default.
- W2255520919 cites W1458931011 @default.
- W2255520919 cites W1497700962 @default.
- W2255520919 cites W1506249422 @default.
- W2255520919 cites W1526269920 @default.
- W2255520919 cites W1544184390 @default.
- W2255520919 cites W1550898241 @default.
- W2255520919 cites W1578779604 @default.
- W2255520919 cites W1633340712 @default.
- W2255520919 cites W1670356458 @default.
- W2255520919 cites W1691756018 @default.
- W2255520919 cites W1742716280 @default.
- W2255520919 cites W1889359478 @default.
- W2255520919 cites W1963482427 @default.
- W2255520919 cites W1963966904 @default.
- W2255520919 cites W1965669554 @default.
- W2255520919 cites W1966136261 @default.
- W2255520919 cites W1967064280 @default.
- W2255520919 cites W1967349402 @default.
- W2255520919 cites W1968301937 @default.
- W2255520919 cites W1968501452 @default.
- W2255520919 cites W1971084392 @default.
- W2255520919 cites W1971765644 @default.
- W2255520919 cites W1974463288 @default.
- W2255520919 cites W1975109347 @default.
- W2255520919 cites W1975507466 @default.
- W2255520919 cites W1982248155 @default.
- W2255520919 cites W1983822447 @default.
- W2255520919 cites W1985871840 @default.
- W2255520919 cites W1990014836 @default.
- W2255520919 cites W1990164134 @default.
- W2255520919 cites W1992286756 @default.
- W2255520919 cites W1994111158 @default.
- W2255520919 cites W1998541478 @default.
- W2255520919 cites W1998717174 @default.
- W2255520919 cites W1999895549 @default.
- W2255520919 cites W2000537420 @default.
- W2255520919 cites W2001296325 @default.
- W2255520919 cites W2002797826 @default.
- W2255520919 cites W2003013703 @default.
- W2255520919 cites W2004313693 @default.
- W2255520919 cites W2004604512 @default.
- W2255520919 cites W2005293673 @default.
- W2255520919 cites W2006270737 @default.
- W2255520919 cites W2009170266 @default.
- W2255520919 cites W2011407996 @default.
- W2255520919 cites W2013696780 @default.
- W2255520919 cites W2015278027 @default.
- W2255520919 cites W2016008825 @default.
- W2255520919 cites W2016703718 @default.
- W2255520919 cites W2016849208 @default.
- W2255520919 cites W2016927241 @default.
- W2255520919 cites W2019095153 @default.
- W2255520919 cites W2022447085 @default.
- W2255520919 cites W2023054181 @default.
- W2255520919 cites W2025032159 @default.
- W2255520919 cites W2028906750 @default.
- W2255520919 cites W2030691041 @default.
- W2255520919 cites W2032044380 @default.
- W2255520919 cites W2034888385 @default.
- W2255520919 cites W2037910727 @default.
- W2255520919 cites W2039265368 @default.
- W2255520919 cites W2040674417 @default.
- W2255520919 cites W2040849682 @default.
- W2255520919 cites W2040931015 @default.
- W2255520919 cites W2043446856 @default.
- W2255520919 cites W2044357091 @default.
- W2255520919 cites W2044763627 @default.
- W2255520919 cites W2044947196 @default.
- W2255520919 cites W2047717400 @default.
- W2255520919 cites W2048647257 @default.
- W2255520919 cites W2049903859 @default.
- W2255520919 cites W2050715985 @default.
- W2255520919 cites W2057967197 @default.
- W2255520919 cites W2058410551 @default.
- W2255520919 cites W2058704052 @default.
- W2255520919 cites W2059751934 @default.
- W2255520919 cites W2060774315 @default.
- W2255520919 cites W2061406619 @default.
- W2255520919 cites W2065886456 @default.
- W2255520919 cites W2065918867 @default.
- W2255520919 cites W2067070931 @default.
- W2255520919 cites W2067323414 @default.
- W2255520919 cites W2067664793 @default.
- W2255520919 cites W2069758725 @default.
- W2255520919 cites W2070307953 @default.
- W2255520919 cites W2070896966 @default.
- W2255520919 cites W2071959081 @default.
- W2255520919 cites W2073478256 @default.
- W2255520919 cites W2075086114 @default.