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- W2255550817 abstract "20100 Background: There is an increased interest on the association between HLA markers and prognostic outcome in several cancer forms. We have previously reported that the high prevalence of the A2 allele in Scandinavia, which decreases with latitude in Europe, correlates to a similar decrease in ovarian cancer mortality among European countries. We have also published the association of this allele with severe prognosis in serous adenocarcinoma of the Ovary in stage III-IV. We now present a complete distribution of the HLA- A, -B -C and DRB1 alleles and haplotypes in relation to histology and clinical stage. Methods: An unbiased selection of epithelial ovarian cancer patients (n = 56) recorded by age, histology, stage and treatment were analyzed for HLA-A, -B, -C and -DRB1 genotypes by PCR/sequence-specific oligonucleotide hybridization procedure (PCR/SSOP). HLA frequencies from healthy Swedish bone marrow donors were used as comparison. Results: HLA-A2, -B7, -B15, -B44 as well as the A2, -B15, -DR4 haplotypes frequency are significantly higher than in the healthy Swedish population. We noticed a high concentration of this haplotypes among the serous adenocarcinomas. Seven patients were homozygotes for A2 allele (23%), two times the healthy Swedish population (12%), and 3 times the median frequency in Europe (8%). Six of these had the haplotype -A2, -B7. Conclusions: HLA-A2 homozygotes and some HLA-A2 -B and -DRb1 haplotypes are higher expressed than in healthy individuals. These observations corroborate the relevance of HLA in association with ovarian cancer, previously partially investigated. Ongoing studies consider the relationship of HLA-A2 and its haplotypes to possible oncogenes and prognosis in ovarian cancer. No significant financial relationships to disclose." @default.
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- W2255550817 date "2006-06-20" @default.
- W2255550817 modified "2023-10-17" @default.
- W2255550817 title "Swedish ovarian cancer patients are found with a high frequency of human leucocyte antigen (HLA) A2, -B7, -B12, -B15 -B44 and -DRB1–4 haplotypes" @default.
- W2255550817 doi "https://doi.org/10.1200/jco.2006.24.18_suppl.20100" @default.
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