FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255593387> ?p ?o ?g. }

• W2255593387 abstract "Genome variability of host genome and cancer cells play critical role in diversity of response to existing therapies and overall success in treating oncological diseases. In chronic myeloid leukemia targeted therapy with tyrosine kinase inhibitors demonstrates high efficacy in most of the patients. However about 15 % of patients demonstrate primary resistance to standard therapy. Whole exome sequencing is a good tool for unbiased search of genetic variations important for prognosis of survival and therapy efficacy in many cancers. We apply this approach to CML patients with optimal response and failure of tyrosine kinase therapy.We analyzed exome variations between optimal responders and failures and found 7 variants in cancer-related genes with different genotypes in two groups of patients. Five of them were found in optimal responders: rs11579366, rs1990236, rs176037, rs10653661, rs3803264 and two in failures: rs3099950, rs9471966. These variants were found in genes associated with cancers (ANKRD35, DNAH9, MAGEC1, TOX3) or participating in cancer-related signaling pathways (THSD1, MORN2, PTCRA).We found gene variants which may become early predictors of the therapy outcome and allow development of new early prognostic tests for estimation of therapy efficacy in CML patients. Normal genetic variation may influence therapy efficacy during targeted treatment of cancers." @default.
• W2255593387 created "2016-06-24" @default.
• W2255593387 creator A5003294629 @default.
• W2255593387 creator A5012015851 @default.
• W2255593387 creator A5054376895 @default.
• W2255593387 creator A5054875291 @default.
• W2255593387 creator A5055021299 @default.
• W2255593387 creator A5059192026 @default.
• W2255593387 creator A5060546352 @default.
• W2255593387 date "2016-01-27" @default.
• W2255593387 modified "2023-10-16" @default.
• W2255593387 title "Frequent variations in cancer-related genes may play prognostic role in treatment of patients with chronic myeloid leukemia" @default.
• W2255593387 cites W1527489494 @default.
• W2255593387 cites W1883695122 @default.
• W2255593387 cites W1964827067 @default.
• W2255593387 cites W1967609586 @default.
• W2255593387 cites W1968747503 @default.
• W2255593387 cites W1981749506 @default.
• W2255593387 cites W1983168420 @default.
• W2255593387 cites W1984068087 @default.
• W2255593387 cites W1992875696 @default.
• W2255593387 cites W1995628893 @default.
• W2255593387 cites W2001475328 @default.
• W2255593387 cites W2016656445 @default.
• W2255593387 cites W2020345691 @default.
• W2255593387 cites W2021341670 @default.
• W2255593387 cites W2025640995 @default.
• W2255593387 cites W2038963685 @default.
• W2255593387 cites W2059145105 @default.
• W2255593387 cites W2060935041 @default.
• W2255593387 cites W2066390791 @default.
• W2255593387 cites W2076467579 @default.
• W2255593387 cites W2086159698 @default.
• W2255593387 cites W2087125879 @default.
• W2255593387 cites W2088326044 @default.
• W2255593387 cites W2100672445 @default.
• W2255593387 cites W2104570606 @default.
• W2255593387 cites W2106169806 @default.
• W2255593387 cites W2106534062 @default.
• W2255593387 cites W2115977771 @default.
• W2255593387 cites W2117131162 @default.
• W2255593387 cites W2121169098 @default.
• W2255593387 cites W2139718893 @default.
• W2255593387 cites W2144045098 @default.
• W2255593387 cites W2152648806 @default.
• W2255593387 cites W2164004777 @default.
• W2255593387 cites W2396911106 @default.
• W2255593387 doi "https://doi.org/10.1186/s12863-015-0308-7" @default.
• W2255593387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4895599" @default.
• W2255593387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26822197" @default.
• W2255593387 hasPublicationYear "2016" @default.
• W2255593387 type Work @default.
• W2255593387 sameAs 2255593387 @default.
• W2255593387 citedByCount "11" @default.
• W2255593387 countsByYear W22555933872016 @default.
• W2255593387 countsByYear W22555933872017 @default.
• W2255593387 countsByYear W22555933872018 @default.
• W2255593387 countsByYear W22555933872019 @default.
• W2255593387 countsByYear W22555933872020 @default.
• W2255593387 countsByYear W22555933872021 @default.
• W2255593387 countsByYear W22555933872022 @default.
• W2255593387 countsByYear W22555933872023 @default.
• W2255593387 crossrefType "journal-article" @default.
• W2255593387 hasAuthorship W2255593387A5003294629 @default.
• W2255593387 hasAuthorship W2255593387A5012015851 @default.
• W2255593387 hasAuthorship W2255593387A5054376895 @default.
• W2255593387 hasAuthorship W2255593387A5054875291 @default.
• W2255593387 hasAuthorship W2255593387A5055021299 @default.
• W2255593387 hasAuthorship W2255593387A5059192026 @default.
• W2255593387 hasAuthorship W2255593387A5060546352 @default.
• W2255593387 hasBestOaLocation W22555933871 @default.
• W2255593387 hasConcept C104317684 @default.
• W2255593387 hasConcept C10590036 @default.
• W2255593387 hasConcept C121608353 @default.
• W2255593387 hasConcept C141231307 @default.
• W2255593387 hasConcept C143998085 @default.
• W2255593387 hasConcept C16671776 @default.
• W2255593387 hasConcept C2778461978 @default.
• W2255593387 hasConcept C2778729363 @default.
• W2255593387 hasConcept C2778820342 @default.
• W2255593387 hasConcept C2781230642 @default.
• W2255593387 hasConcept C501734568 @default.
• W2255593387 hasConcept C502942594 @default.
• W2255593387 hasConcept C54355233 @default.
• W2255593387 hasConcept C60644358 @default.
• W2255593387 hasConcept C71924100 @default.
• W2255593387 hasConcept C86803240 @default.
• W2255593387 hasConceptScore W2255593387C104317684 @default.
• W2255593387 hasConceptScore W2255593387C10590036 @default.
• W2255593387 hasConceptScore W2255593387C121608353 @default.
• W2255593387 hasConceptScore W2255593387C141231307 @default.
• W2255593387 hasConceptScore W2255593387C143998085 @default.
• W2255593387 hasConceptScore W2255593387C16671776 @default.
• W2255593387 hasConceptScore W2255593387C2778461978 @default.
• W2255593387 hasConceptScore W2255593387C2778729363 @default.
• W2255593387 hasConceptScore W2255593387C2778820342 @default.
• W2255593387 hasConceptScore W2255593387C2781230642 @default.
• W2255593387 hasConceptScore W2255593387C501734568 @default.
• W2255593387 hasConceptScore W2255593387C502942594 @default.
• W2255593387 hasConceptScore W2255593387C54355233 @default.

• next