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• W2255607364 abstract "Four new tetracyclic meroterpnes, dysiherbols A–C (1–3) and dysideanone E (4), were isolated from a Dysidea sp. marine sponge collected from the South China Sea. Their complete structures and absolute configurations were unambiguously determined by a combination of NMR spectroscopic data, ECD calculations, and single-crystal X-ray diffraction analysis. Within the sesquiterpene quinol structures, dysiherbols A–C possess an intriguing 6/6/5/6-fused tetracyclic carbon skeleton. The NF-κB inhibitory and cytotoxic activity evaluation disclosed that dysiherbol A (1) showed potent activity with respective IC50 values of 0.49 and 0.58 μM, which were about 10-fold and 20-fold more potent than those of dysiherbols B (2) and C (3), which feature hydroxy and ketone carbonyl groups at the C-3 position." @default.
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• W2255607364 date "2016-02-10" @default.
• W2255607364 modified "2023-10-14" @default.
• W2255607364 title "Dysiherbols A–C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from a <i>Dysidea</i> sp. Marine Sponge" @default.
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• W2255607364 doi "https://doi.org/10.1021/acs.jnatprod.5b01079" @default.
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