FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255622689> ?p ?o ?g. }

• W2255622689 endingPage "6" @default.
• W2255622689 startingPage "1" @default.
• W2255622689 abstract "Liver cancer is the fifth most common malignance in the world. It has been known that 90% of liver cancers are hepatocellular carcinoma (HCC). It is estimated that more than 740,000 new cases of HCC were diagnosed and approximately 700,000 deaths were occurred worldwide. In the USA, 35,660 people will be diagnosed with HCC and 24,550 patients will die from HCC in year 2015. In China, more than 400,000 new cases will be developed and 370,000 patients will die due to this deadly disease. Although surgical resection and liver transplantation have been improved, the 5-year survival rate has no significant decrease in part due to the fact that most patients are in the late stage at diagnosis. Additionally, many HCC patients exhibit low sensitivity to standard radiotherapy and chemotherapy. For example, sorafenib is the standard drug for the treatment of advanced HCC cases; however, the median overall survival of these HCC patients is still less than 1 year partly due to drug resistance. Therefore, it is pivotal to discover the new therapeutic drugs for the treatment of HCC patients. Emerging evidence has suggested that hepatitis C virus (HCV) and hepatitis B virus (HBV) infection are important risk factors for the incidence of HCC. In addition, obesity, diabetes and nonalcoholic steatohepatitis have been found to contribute to HCC incidence. Without a doubt, the presence of cirrhosis is the overriding risk factor for HCC. In recent years, several lines of evidence has defined that some genes and cellular signaling pathways play a key role in the development and progression of HCC, including Notch, PI3K (phosphatidylinositol 3-Kinase)/Akt, extracellularregulated kinase (ERK), mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK), Hedeghog, and Wnt pathways. Moreover, some growth factor signaling pathways such as epidermal growth factor (EGF), hepatocyte growth factor (HGF), insulin-like growth factor (IGF), transforming growth factor (TGF), platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) have also been emerged as critical players in tumorigenesis including liver carcinogenesis. Among some of these pathways, FGF has recently gained high attention in HCC development and progression. Therefore, in this article, we will briefly describe recent advances in the physiological function and molecular mechanism of FGF in HCC. We also present the current chemical inhibitors of FGF/FGFR and natural agents that inactivate FGF signaling pathway. Lastly, we will discuss whether FGF/FGFR could be the prognostic markers and/ or potential targets for the treatment of HCC patients." @default.
• W2255622689 created "2016-06-24" @default.
• W2255622689 creator A5005394879 @default.
• W2255622689 creator A5016150318 @default.
• W2255622689 creator A5082599988 @default.
• W2255622689 date "2016-02-01" @default.
• W2255622689 modified "2023-09-29" @default.
• W2255622689 title "Emerging roles of FGF signaling in hepatocellular carcinoma." @default.
• W2255622689 cites W1482499908 @default.
• W2255622689 cites W1507996114 @default.
• W2255622689 cites W1551181565 @default.
• W2255622689 cites W1574542346 @default.
• W2255622689 cites W1793883175 @default.
• W2255622689 cites W1826437673 @default.
• W2255622689 cites W1863396492 @default.
• W2255622689 cites W1965358479 @default.
• W2255622689 cites W1981989535 @default.
• W2255622689 cites W1982132411 @default.
• W2255622689 cites W1982154889 @default.
• W2255622689 cites W1988476050 @default.
• W2255622689 cites W1991070017 @default.
• W2255622689 cites W1996958662 @default.
• W2255622689 cites W2001297027 @default.
• W2255622689 cites W2001896210 @default.
• W2255622689 cites W2002877827 @default.
• W2255622689 cites W2003793248 @default.
• W2255622689 cites W2013424084 @default.
• W2255622689 cites W2015816582 @default.
• W2255622689 cites W2016884881 @default.
• W2255622689 cites W2018992554 @default.
• W2255622689 cites W2021181675 @default.
• W2255622689 cites W2026413283 @default.
• W2255622689 cites W2027239974 @default.
• W2255622689 cites W2029548412 @default.
• W2255622689 cites W2031597668 @default.
• W2255622689 cites W2034198983 @default.
• W2255622689 cites W2052700419 @default.
• W2255622689 cites W2061743943 @default.
• W2255622689 cites W2063106327 @default.
• W2255622689 cites W2063746351 @default.
• W2255622689 cites W2077264941 @default.
• W2255622689 cites W2086887894 @default.
• W2255622689 cites W2090277764 @default.
• W2255622689 cites W2093619650 @default.
• W2255622689 cites W2094901854 @default.
• W2255622689 cites W2099088565 @default.
• W2255622689 cites W2101004105 @default.
• W2255622689 cites W2118471405 @default.
• W2255622689 cites W2121423336 @default.
• W2255622689 cites W2130787560 @default.
• W2255622689 cites W2136970568 @default.
• W2255622689 cites W2141980602 @default.
• W2255622689 cites W2143385760 @default.
• W2255622689 cites W2155413391 @default.
• W2255622689 cites W2170552969 @default.
• W2255622689 cites W2171990314 @default.
• W2255622689 cites W2196397027 @default.
• W2255622689 cites W2209465445 @default.
• W2255622689 cites W2233335920 @default.
• W2255622689 cites W2236909404 @default.
• W2255622689 cites W2917837889 @default.
• W2255622689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4876964" @default.
• W2255622689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27226954" @default.
• W2255622689 hasPublicationYear "2016" @default.
• W2255622689 type Work @default.
• W2255622689 sameAs 2255622689 @default.
• W2255622689 citedByCount "13" @default.
• W2255622689 countsByYear W22556226892016 @default.
• W2255622689 countsByYear W22556226892018 @default.
• W2255622689 countsByYear W22556226892019 @default.
• W2255622689 countsByYear W22556226892021 @default.
• W2255622689 countsByYear W22556226892022 @default.
• W2255622689 crossrefType "journal-article" @default.
• W2255622689 hasAuthorship W2255622689A5005394879 @default.
• W2255622689 hasAuthorship W2255622689A5016150318 @default.
• W2255622689 hasAuthorship W2255622689A5082599988 @default.
• W2255622689 hasConcept C120665830 @default.
• W2255622689 hasConcept C121332964 @default.
• W2255622689 hasConcept C121608353 @default.
• W2255622689 hasConcept C126322002 @default.
• W2255622689 hasConcept C143998085 @default.
• W2255622689 hasConcept C203014093 @default.
• W2255622689 hasConcept C2522874641 @default.
• W2255622689 hasConcept C2776231280 @default.
• W2255622689 hasConcept C2777214474 @default.
• W2255622689 hasConcept C2777382497 @default.
• W2255622689 hasConcept C2778019345 @default.
• W2255622689 hasConcept C2778695046 @default.
• W2255622689 hasConcept C2779609443 @default.
• W2255622689 hasConcept C2780593183 @default.
• W2255622689 hasConcept C2911091166 @default.
• W2255622689 hasConcept C61511704 @default.
• W2255622689 hasConcept C71924100 @default.
• W2255622689 hasConcept C90924648 @default.
• W2255622689 hasConceptScore W2255622689C120665830 @default.
• W2255622689 hasConceptScore W2255622689C121332964 @default.
• W2255622689 hasConceptScore W2255622689C121608353 @default.
• W2255622689 hasConceptScore W2255622689C126322002 @default.

• next