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- W2255623752 endingPage "504" @default.
- W2255623752 startingPage "494" @default.
- W2255623752 abstract "The DNA repair enzyme AlkB was identified in E. coli more than three decades ago. Since then, nine mammalian homologs, all members of the superfamily of alpha-ketoglutarate and Fe(II)-dependent dioxygenases, have been identified (designated ALKBH1–8 and FTO). While E. coli AlkB serves as a DNA repair enzyme, only two mammalian homologs have been confirmed to repair DNA in vivo. The other mammalian homologs have remarkably diverse substrate specificities and biological functions. Substrates recognized by the different AlkB homologs comprise erroneous methyl- and etheno adducts in DNA, unique wobble uridine modifications in certain tRNAs, methylated adenines in mRNA, and methylated lysines on proteins. The phenotypes of organisms lacking or overexpressing individual AlkB homologs include obesity, severe sensitivity to inflammation, infertility, growth retardation, and multiple malformations. Here we review the present knowledge of the mammalian AlkB homologs and their implications for human disease and development." @default.
- W2255623752 created "2016-06-24" @default.
- W2255623752 creator A5007536195 @default.
- W2255623752 creator A5007799477 @default.
- W2255623752 creator A5039624519 @default.
- W2255623752 creator A5040035445 @default.
- W2255623752 date "2015-05-23" @default.
- W2255623752 modified "2023-10-16" @default.
- W2255623752 title "Non-homologous functions of the AlkB homologs" @default.
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