FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255641665> ?p ?o ?g. }

• W2255641665 endingPage "638" @default.
• W2255641665 startingPage "632" @default.
• W2255641665 abstract "OBJECTIVE Nonalcoholic steatohepatitis (NASH) is increasingly common in obese patients. However, its metabolic consequences in patients with type 2 diabetes mellitus (T2DM) are unknown. RESEARCH DESIGN AND METHODS We studied 154 obese patients divided in four groups: 1) control (no T2DM or NAFLD), 2) T2DM without NAFLD, 3) T2DM with isolated steatosis, and 4) T2DM with NASH. We evaluated intrahepatic triglycerides by proton MRS (1H-MRS) and assessed insulin secretion/resistance during an oral glucose tolerance test and a euglycemic-hyperinsulinemic clamp with glucose turnover measurements. RESULTS No significant differences among groups were observed in sex, BMI, or total body fat. Metabolic parameters worsened progressively with the presence of T2DM and the development of hepatic steatosis, with worse hyperinsulinemia, insulin resistance, and dyslipidemia (hypertriglyceridemia and low HDL cholesterol) in those with NASH (P &lt; 0.001). Compared with isolated steatosis, NASH was associated with more dysfunctional and insulin-resistant adipose tissue (either as insulin suppression of plasma FFA [33 ± 3 vs. 48 ± 6%] or adipose tissue insulin resistance index [9.8 ± 1.0 vs. 5.9 ± 0.8 mmol/L ⋅ µIU/mL]; both P &lt; 0.03). Furthermore, insulin suppression of plasma FFA correlated well with hepatic steatosis (r = –0.62; P &lt; 0.001) and severity of steatohepatitis (rs = −0.52; P &lt; 0.001). Hepatic insulin sensitivity was also more significantly impaired among patients with T2DM and NASH, both fasting and with increasing insulin levels within the physiological range (10 to 140 µIU/mL), compared with other groups. CONCLUSIONS In obese patients with T2DM, the presence of NAFLD is associated with more severe hyperinsulinemia, dyslipidemia, and adipose tissue/hepatic insulin resistance compared with patients without NAFLD. The unfavorable metabolic profile linked to NAFLD should prompt strategies to identify and treat this population early on." @default.
• W2255641665 created "2016-06-24" @default.
• W2255641665 creator A5004123674 @default.
• W2255641665 creator A5010014173 @default.
• W2255641665 creator A5027629341 @default.
• W2255641665 creator A5027677085 @default.
• W2255641665 creator A5035588436 @default.
• W2255641665 creator A5036605658 @default.
• W2255641665 creator A5039000980 @default.
• W2255641665 creator A5056877243 @default.
• W2255641665 creator A5079929937 @default.
• W2255641665 creator A5086957117 @default.
• W2255641665 date "2016-02-09" @default.
• W2255641665 modified "2023-10-12" @default.
• W2255641665 title "Metabolic Impact of Nonalcoholic Steatohepatitis in Obese Patients With Type 2 Diabetes" @default.
• W2255641665 cites W1856151485 @default.
• W2255641665 cites W1974988072 @default.
• W2255641665 cites W1975388439 @default.
• W2255641665 cites W1981456793 @default.
• W2255641665 cites W1985236262 @default.
• W2255641665 cites W2000545769 @default.
• W2255641665 cites W2009760123 @default.
• W2255641665 cites W2028962874 @default.
• W2255641665 cites W2059251195 @default.
• W2255641665 cites W2067507037 @default.
• W2255641665 cites W2074203821 @default.
• W2255641665 cites W2077210083 @default.
• W2255641665 cites W2080094617 @default.
• W2255641665 cites W2098555833 @default.
• W2255641665 cites W2103135709 @default.
• W2255641665 cites W2103156933 @default.
• W2255641665 cites W2105912552 @default.
• W2255641665 cites W2107314043 @default.
• W2255641665 cites W2107483470 @default.
• W2255641665 cites W2107943478 @default.
• W2255641665 cites W2112291880 @default.
• W2255641665 cites W2114618441 @default.
• W2255641665 cites W2120056458 @default.
• W2255641665 cites W2123612027 @default.
• W2255641665 cites W2124464501 @default.
• W2255641665 cites W2126285374 @default.
• W2255641665 cites W2128157888 @default.
• W2255641665 cites W2132477505 @default.
• W2255641665 cites W2136226749 @default.
• W2255641665 cites W2136795008 @default.
• W2255641665 cites W2136909828 @default.
• W2255641665 cites W2141065273 @default.
• W2255641665 cites W2159896083 @default.
• W2255641665 cites W2161780395 @default.
• W2255641665 cites W2162819835 @default.
• W2255641665 cites W2164361277 @default.
• W2255641665 cites W2168763055 @default.
• W2255641665 cites W2170328050 @default.
• W2255641665 cites W2209256668 @default.
• W2255641665 cites W2518856513 @default.
• W2255641665 cites W4214826712 @default.
• W2255641665 cites W4293860580 @default.
• W2255641665 doi "https://doi.org/10.2337/dc15-1876" @default.
• W2255641665 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5864108" @default.
• W2255641665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26861926" @default.
• W2255641665 hasPublicationYear "2016" @default.
• W2255641665 type Work @default.
• W2255641665 sameAs 2255641665 @default.
• W2255641665 citedByCount "102" @default.
• W2255641665 countsByYear W22556416652016 @default.
• W2255641665 countsByYear W22556416652017 @default.
• W2255641665 countsByYear W22556416652018 @default.
• W2255641665 countsByYear W22556416652019 @default.
• W2255641665 countsByYear W22556416652020 @default.
• W2255641665 countsByYear W22556416652021 @default.
• W2255641665 countsByYear W22556416652022 @default.
• W2255641665 countsByYear W22556416652023 @default.
• W2255641665 crossrefType "journal-article" @default.
• W2255641665 hasAuthorship W2255641665A5004123674 @default.
• W2255641665 hasAuthorship W2255641665A5010014173 @default.
• W2255641665 hasAuthorship W2255641665A5027629341 @default.
• W2255641665 hasAuthorship W2255641665A5027677085 @default.
• W2255641665 hasAuthorship W2255641665A5035588436 @default.
• W2255641665 hasAuthorship W2255641665A5036605658 @default.
• W2255641665 hasAuthorship W2255641665A5039000980 @default.
• W2255641665 hasAuthorship W2255641665A5056877243 @default.
• W2255641665 hasAuthorship W2255641665A5079929937 @default.
• W2255641665 hasAuthorship W2255641665A5086957117 @default.
• W2255641665 hasBestOaLocation W22556416651 @default.
• W2255641665 hasConcept C126322002 @default.
• W2255641665 hasConcept C134018914 @default.
• W2255641665 hasConcept C171089720 @default.
• W2255641665 hasConcept C2776175330 @default.
• W2255641665 hasConcept C2776919658 @default.
• W2255641665 hasConcept C2777180221 @default.
• W2255641665 hasConcept C2777391703 @default.
• W2255641665 hasConcept C2778096610 @default.
• W2255641665 hasConcept C2778163477 @default.
• W2255641665 hasConcept C2778772119 @default.
• W2255641665 hasConcept C2778913445 @default.
• W2255641665 hasConcept C2779134260 @default.
• W2255641665 hasConcept C2779306644 @default.
• W2255641665 hasConcept C2779478299 @default.

• next