Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255798897> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2255798897 abstract "This paper highlights two variables, neglected by economists, that I argue are important in explaining patterns of innovation seen in vaccines and perhaps in other parts of medicine too. They are: firstly, the extent to which it is safe to experiment on humans; and secondly, whether good animal models can be identified and used, with the latter especially important if there are strong constraints on experimenting with humans. To consider the argument, the paper discusses the case of vaccines, where the political economy of R&D appears to explain only part of the observed variation. I focus on HIV vaccine development and find that, together, these two variables not only make up a large part of how I would characterize ‘difficulty’ in the HIV R&D process, but they also seem to go a long way towards explaining why 31 other diseases have – or have not had vaccines developed for them. In characterizing these variables, I discuss what might happen if we choose to persist in difficult R&D domains, finding that development may be forced into trajectories that yield lower quality products. Counter intuitively, such lower quality products are typically more expensive because they are harder to pass through clinical trials. Implications for theory and policy are discussed, chief of which are that the technical difficulty of R&D is not fixed and can be shifted by policy, and that difficult R&D trajectories need not be pursued when alternative trajectories can be developed." @default.
- W2255798897 created "2016-06-24" @default.
- W2255798897 creator A5042551841 @default.
- W2255798897 date "2015-01-01" @default.
- W2255798897 modified "2023-09-27" @default.
- W2255798897 title "Explaining Variation in Medical Innovation: The Case of Vaccines, and the HIV AIDS Effort" @default.
- W2255798897 cites W3125658974 @default.
- W2255798897 cites W610606647 @default.
- W2255798897 doi "https://doi.org/10.2139/ssrn.2744686" @default.
- W2255798897 hasPublicationYear "2015" @default.
- W2255798897 type Work @default.
- W2255798897 sameAs 2255798897 @default.
- W2255798897 citedByCount "2" @default.
- W2255798897 countsByYear W22557988972016 @default.
- W2255798897 crossrefType "journal-article" @default.
- W2255798897 hasAuthorship W2255798897A5042551841 @default.
- W2255798897 hasConcept C100001284 @default.
- W2255798897 hasConcept C111472728 @default.
- W2255798897 hasConcept C111919701 @default.
- W2255798897 hasConcept C118084267 @default.
- W2255798897 hasConcept C121332964 @default.
- W2255798897 hasConcept C126322002 @default.
- W2255798897 hasConcept C134121241 @default.
- W2255798897 hasConcept C138885662 @default.
- W2255798897 hasConcept C162324750 @default.
- W2255798897 hasConcept C17744445 @default.
- W2255798897 hasConcept C191897082 @default.
- W2255798897 hasConcept C192562407 @default.
- W2255798897 hasConcept C199539241 @default.
- W2255798897 hasConcept C203014093 @default.
- W2255798897 hasConcept C2778190748 @default.
- W2255798897 hasConcept C2778334786 @default.
- W2255798897 hasConcept C2779530757 @default.
- W2255798897 hasConcept C2780195530 @default.
- W2255798897 hasConcept C3013748606 @default.
- W2255798897 hasConcept C41008148 @default.
- W2255798897 hasConcept C44870925 @default.
- W2255798897 hasConcept C71924100 @default.
- W2255798897 hasConcept C94625758 @default.
- W2255798897 hasConcept C98045186 @default.
- W2255798897 hasConcept C98184364 @default.
- W2255798897 hasConceptScore W2255798897C100001284 @default.
- W2255798897 hasConceptScore W2255798897C111472728 @default.
- W2255798897 hasConceptScore W2255798897C111919701 @default.
- W2255798897 hasConceptScore W2255798897C118084267 @default.
- W2255798897 hasConceptScore W2255798897C121332964 @default.
- W2255798897 hasConceptScore W2255798897C126322002 @default.
- W2255798897 hasConceptScore W2255798897C134121241 @default.
- W2255798897 hasConceptScore W2255798897C138885662 @default.
- W2255798897 hasConceptScore W2255798897C162324750 @default.
- W2255798897 hasConceptScore W2255798897C17744445 @default.
- W2255798897 hasConceptScore W2255798897C191897082 @default.
- W2255798897 hasConceptScore W2255798897C192562407 @default.
- W2255798897 hasConceptScore W2255798897C199539241 @default.
- W2255798897 hasConceptScore W2255798897C203014093 @default.
- W2255798897 hasConceptScore W2255798897C2778190748 @default.
- W2255798897 hasConceptScore W2255798897C2778334786 @default.
- W2255798897 hasConceptScore W2255798897C2779530757 @default.
- W2255798897 hasConceptScore W2255798897C2780195530 @default.
- W2255798897 hasConceptScore W2255798897C3013748606 @default.
- W2255798897 hasConceptScore W2255798897C41008148 @default.
- W2255798897 hasConceptScore W2255798897C44870925 @default.
- W2255798897 hasConceptScore W2255798897C71924100 @default.
- W2255798897 hasConceptScore W2255798897C94625758 @default.
- W2255798897 hasConceptScore W2255798897C98045186 @default.
- W2255798897 hasConceptScore W2255798897C98184364 @default.
- W2255798897 hasLocation W22557988971 @default.
- W2255798897 hasOpenAccess W2255798897 @default.
- W2255798897 hasPrimaryLocation W22557988971 @default.
- W2255798897 hasRelatedWork W2070723088 @default.
- W2255798897 hasRelatedWork W2126846316 @default.
- W2255798897 hasRelatedWork W2158438518 @default.
- W2255798897 hasRelatedWork W2160055435 @default.
- W2255798897 hasRelatedWork W2245518343 @default.
- W2255798897 hasRelatedWork W2279527086 @default.
- W2255798897 hasRelatedWork W2283761429 @default.
- W2255798897 hasRelatedWork W2321719041 @default.
- W2255798897 hasRelatedWork W2371661120 @default.
- W2255798897 hasRelatedWork W2467575677 @default.
- W2255798897 hasRelatedWork W2587453069 @default.
- W2255798897 hasRelatedWork W276386196 @default.
- W2255798897 hasRelatedWork W2997396722 @default.
- W2255798897 hasRelatedWork W304393122 @default.
- W2255798897 hasRelatedWork W3099587150 @default.
- W2255798897 hasRelatedWork W3121920514 @default.
- W2255798897 hasRelatedWork W3124324829 @default.
- W2255798897 hasRelatedWork W3125389492 @default.
- W2255798897 hasRelatedWork W2108833562 @default.
- W2255798897 hasRelatedWork W2602429430 @default.
- W2255798897 isParatext "false" @default.
- W2255798897 isRetracted "false" @default.
- W2255798897 magId "2255798897" @default.
- W2255798897 workType "article" @default.