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- W2255830701 abstract "Reaction time (RT), the most common measure of CNS efficiency, shows intra- and inter-individual variability. This may be accounted for by hemispheric specialization, individual neuroanatomy, and transient functional fluctuations between trials. To explore RT on these three levels, ERPs were measured in a visual 4-choice RT task with lateralized stimuli (left lateral, left middle, right middle, and right lateral) in 28 healthy right-handed subjects. We analyzed behavioral data, ERP microstates (MS), N1 and P3 components, and trial-by-trial variance. Across subjects, the N1 component was contralateral to the stimulation side. N1-MSs were stronger over the left hemisphere, and middle stimulation evoked stronger activation than lateral stimulation in both hemispheres. The P3 was larger for the right visual field stimulation. RTs were shorter for the right visual hemifield stimulation/right hand responses. Within subjects, covariance analysis of single trial ERPs with RTs showed consistent lateralized predictors of RT over the motor cortex (MC) in the 112–248 ms interval. Decreased RTs were related to negativity over the MC contralateral to the stimulation side, an effect that could be interpreted as the lateralized readiness potential (LRP), and which was strongest for right side stimulation. The covariance analysis linking individual mean RTs and individual mean ERPs showed a frontal negativity and an occipital positivity correlating with decreased RTs in the 212–232 ms interval. We concluded that a particular RT is a composite measure that depends on the appropriateness of the motor preparation to a particular response and on stimulus lateralization that selectively involves a particular hemisphere." @default.
- W2255830701 created "2016-06-24" @default.
- W2255830701 creator A5013044222 @default.
- W2255830701 creator A5051467889 @default.
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- W2255830701 creator A5066778919 @default.
- W2255830701 creator A5068192515 @default.
- W2255830701 creator A5087764117 @default.
- W2255830701 date "2016-01-30" @default.
- W2255830701 modified "2023-09-26" @default.
- W2255830701 title "Reaction Time in a Visual 4-Choice Reaction Time Task: ERP Effects of Motor Preparation and Hemispheric Involvement" @default.
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