Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255845924> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2255845924 endingPage "4" @default.
- W2255845924 startingPage "940" @default.
- W2255845924 abstract "The effect of EM-523 [de(N-methyl)-N-ethyl-8,9-anhydroerythromycin A 6,9-hemiacetal], an erythromycin derivative, on preparations of isolated intestine of rabbits, rats and guinea pigs was investigated and compared to the effects of motilin and prostaglandin F2 alpha (PGF2 alpha). EM-523 and motilin induced contractions in the rabbit intestinal preparations but not in the rat or guinea pig preparations. In contrast, PGF2 alpha induced contractions in all three intestinal preparations. The rabbit duodenum and jejunum were more sensitive than the ileum to EM-523 and motilin, but no selectivity was observed with PGF2 alpha. The contractile responses induced by EM-523 and by motilin were not influenced by pretreatment with tetrodotoxin, atropine, naloxone or mepyramine but were greatly suppressed by pretreatment with verapamil or removal of calcium ions from the medium, suggesting that both agents induce intestinal contractions by acting directly on smooth muscle and that their actions depend largely on extracellular calcium. The contractile response to EM-523 or motilin was reduced markedly after treatment of the preparation with a high concentration of either agent, and cross-tachyphylaxis between EM-523 and motilin was also observed. These findings indicate that the contractile activity of EM-523 is very similar to that of motilin and that EM-523 and motilin may share the same site of action." @default.
- W2255845924 created "2016-06-24" @default.
- W2255845924 creator A5045164227 @default.
- W2255845924 creator A5055559182 @default.
- W2255845924 creator A5073229696 @default.
- W2255845924 creator A5074204610 @default.
- W2255845924 creator A5076500328 @default.
- W2255845924 creator A5077533509 @default.
- W2255845924 date "1990-09-01" @default.
- W2255845924 modified "2023-10-18" @default.
- W2255845924 title "EM-523, an erythromycin derivative, and motilin show similar contractile activity in isolated rabbit intestine." @default.
- W2255845924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2395122" @default.
- W2255845924 hasPublicationYear "1990" @default.
- W2255845924 type Work @default.
- W2255845924 sameAs 2255845924 @default.
- W2255845924 citedByCount "14" @default.
- W2255845924 countsByYear W22558459242019 @default.
- W2255845924 countsByYear W22558459242021 @default.
- W2255845924 crossrefType "journal-article" @default.
- W2255845924 hasAuthorship W2255845924A5045164227 @default.
- W2255845924 hasAuthorship W2255845924A5055559182 @default.
- W2255845924 hasAuthorship W2255845924A5073229696 @default.
- W2255845924 hasAuthorship W2255845924A5074204610 @default.
- W2255845924 hasAuthorship W2255845924A5076500328 @default.
- W2255845924 hasAuthorship W2255845924A5077533509 @default.
- W2255845924 hasConcept C126322002 @default.
- W2255845924 hasConcept C131793682 @default.
- W2255845924 hasConcept C134018914 @default.
- W2255845924 hasConcept C168481208 @default.
- W2255845924 hasConcept C185592680 @default.
- W2255845924 hasConcept C2775859210 @default.
- W2255845924 hasConcept C2775893369 @default.
- W2255845924 hasConcept C2776366702 @default.
- W2255845924 hasConcept C2776741303 @default.
- W2255845924 hasConcept C2777022698 @default.
- W2255845924 hasConcept C2777226302 @default.
- W2255845924 hasConcept C2778815084 @default.
- W2255845924 hasConcept C519063684 @default.
- W2255845924 hasConcept C71924100 @default.
- W2255845924 hasConcept C86803240 @default.
- W2255845924 hasConcept C98274493 @default.
- W2255845924 hasConceptScore W2255845924C126322002 @default.
- W2255845924 hasConceptScore W2255845924C131793682 @default.
- W2255845924 hasConceptScore W2255845924C134018914 @default.
- W2255845924 hasConceptScore W2255845924C168481208 @default.
- W2255845924 hasConceptScore W2255845924C185592680 @default.
- W2255845924 hasConceptScore W2255845924C2775859210 @default.
- W2255845924 hasConceptScore W2255845924C2775893369 @default.
- W2255845924 hasConceptScore W2255845924C2776366702 @default.
- W2255845924 hasConceptScore W2255845924C2776741303 @default.
- W2255845924 hasConceptScore W2255845924C2777022698 @default.
- W2255845924 hasConceptScore W2255845924C2777226302 @default.
- W2255845924 hasConceptScore W2255845924C2778815084 @default.
- W2255845924 hasConceptScore W2255845924C519063684 @default.
- W2255845924 hasConceptScore W2255845924C71924100 @default.
- W2255845924 hasConceptScore W2255845924C86803240 @default.
- W2255845924 hasConceptScore W2255845924C98274493 @default.
- W2255845924 hasIssue "3" @default.
- W2255845924 hasLocation W22558459241 @default.
- W2255845924 hasOpenAccess W2255845924 @default.
- W2255845924 hasPrimaryLocation W22558459241 @default.
- W2255845924 hasRelatedWork W2009045387 @default.
- W2255845924 hasRelatedWork W2013812457 @default.
- W2255845924 hasRelatedWork W2015748227 @default.
- W2255845924 hasRelatedWork W2019325967 @default.
- W2255845924 hasRelatedWork W2039552840 @default.
- W2255845924 hasRelatedWork W2061250924 @default.
- W2255845924 hasRelatedWork W2085361427 @default.
- W2255845924 hasRelatedWork W2091835102 @default.
- W2255845924 hasRelatedWork W2172700117 @default.
- W2255845924 hasRelatedWork W2255845924 @default.
- W2255845924 hasVolume "254" @default.
- W2255845924 isParatext "false" @default.
- W2255845924 isRetracted "false" @default.
- W2255845924 magId "2255845924" @default.
- W2255845924 workType "article" @default.