Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255989330> ?p ?o ?g. }
- W2255989330 abstract "Abstract Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma. To explore the mechanism by which Ca 2+ blocks intercellular communication during tissue injury, we determined the X-ray crystal structures of the human Cx26 gap junction channel with and without bound Ca 2+ . The two structures were nearly identical, ruling out both a large-scale structural change and a local steric constriction of the pore. Ca 2+ coordination sites reside at the interfaces between adjacent subunits, near the entrance to the extracellular gap, where local, side chain conformational rearrangements enable Ca 2+ chelation. Computational analysis revealed that Ca 2+ -binding generates a positive electrostatic barrier that substantially inhibits permeation of cations such as K + into the pore. Our results provide structural evidence for a unique mechanism of channel regulation: ionic conduction block via an electrostatic barrier rather than steric occlusion of the channel pore." @default.
- W2255989330 created "2016-06-24" @default.
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- W2255989330 date "2016-01-12" @default.
- W2255989330 modified "2023-10-06" @default.
- W2255989330 title "An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels" @default.
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- W2255989330 cites W183185412 @default.
- W2255989330 cites W1846377272 @default.
- W2255989330 cites W1963739837 @default.
- W2255989330 cites W1966386328 @default.
- W2255989330 cites W1972920523 @default.
- W2255989330 cites W1979492365 @default.
- W2255989330 cites W1987391644 @default.
- W2255989330 cites W1987687491 @default.
- W2255989330 cites W1988085802 @default.
- W2255989330 cites W1989667983 @default.
- W2255989330 cites W1989703225 @default.
- W2255989330 cites W1990176114 @default.
- W2255989330 cites W1994344006 @default.
- W2255989330 cites W1994565825 @default.
- W2255989330 cites W1997240546 @default.
- W2255989330 cites W2001641653 @default.
- W2255989330 cites W2003821834 @default.
- W2255989330 cites W2007552499 @default.
- W2255989330 cites W2013475033 @default.
- W2255989330 cites W2013742343 @default.
- W2255989330 cites W2016665408 @default.
- W2255989330 cites W2016673032 @default.
- W2255989330 cites W2017932524 @default.
- W2255989330 cites W2024461475 @default.
- W2255989330 cites W2029087609 @default.
- W2255989330 cites W2029277233 @default.
- W2255989330 cites W2029667189 @default.
- W2255989330 cites W2031288682 @default.
- W2255989330 cites W2033032294 @default.
- W2255989330 cites W204998232 @default.
- W2255989330 cites W2062081085 @default.
- W2255989330 cites W2063115321 @default.
- W2255989330 cites W2063831812 @default.
- W2255989330 cites W2066414494 @default.
- W2255989330 cites W2073920564 @default.
- W2255989330 cites W2078998148 @default.
- W2255989330 cites W2085326557 @default.
- W2255989330 cites W2085924667 @default.
- W2255989330 cites W2087742793 @default.
- W2255989330 cites W2089345692 @default.
- W2255989330 cites W2096588775 @default.
- W2255989330 cites W2098338329 @default.
- W2255989330 cites W2104670448 @default.
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- W2255989330 cites W2110697899 @default.
- W2255989330 cites W2119199594 @default.
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- W2255989330 cites W2124026197 @default.
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- W2255989330 cites W2132262459 @default.
- W2255989330 cites W2132478632 @default.
- W2255989330 cites W2138113666 @default.
- W2255989330 cites W2146080841 @default.
- W2255989330 cites W2147611167 @default.
- W2255989330 cites W2148657189 @default.
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- W2255989330 cites W2166189591 @default.
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- W2255989330 cites W2180229411 @default.
- W2255989330 cites W2330314962 @default.
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- W2255989330 doi "https://doi.org/10.1038/ncomms9770" @default.
- W2255989330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4730032" @default.
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- W2255989330 hasPublicationYear "2016" @default.
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